STING Agonist C11

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 µM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1beta, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 µM, respectively), an effect that is dependent on the presence of STING and the IFN-alpha/beta receptor (IFNAR).Formal Name: N-[(methylamino)carbonyl]-alpha-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-benzeneacetamide. CAS Number: 875863-22-2. Synonyms: Stimulator of Interferon Genes Agonist C11. Molecular Formula: C19H18N4O3S. Formula Weight: 382.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble. lambdamax: 274 nm. SMILES: O=C(NC(NC)=O)C(SC1=NN=C(C2=CC=C(C)C=C2)O1)C3=CC=CC=C3. InChi Code: InChI=1S/C19H18N4O3S/c1-12-8-10-14(11-9-12)17-22-23-19(26-17)27-15(13-6-4-3-5-7-13)16(24)21-18(25)20-2/h3-11,15H,1-2H3,(H2,20,21,24,25). InChi Key: KQKWXSQTTDLZSO-UHFFFAOYSA-N.