SR 1555 (hydrochloride)

Retinoic acid receptor-related nuclear receptor gamma (RORgamma) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 1555 is a selective ligand of RORgamma (IC50 = 1 µM). It does not bind RORalpha, LXR, or FXR. SR 1555 acts as an inverse agonist of RORgamma, inhibiting endogenous IL-17A gene expression in mouse splenocytes and suppressing differentiation of TH17 cells when cultured under TH17 polarizing conditions. Moreover, SR 1555 stimulates T regulatory development when cultured under T regulatory polarizing conditions, unlike digoxin and ursolic acid.Formal Name: 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-ethanone, monohydrochloride. CAS Number: 2309312-90-9. Molecular Formula: C22H22F6N2O2 . HCl. Formula Weight: 496.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.16 mg/ml, DMSO: 3 mg/ml, Ethanol: 1.6 mg/ml. lambdamax: 203, 257 nm. SMILES: O=C(C)N(CC1)CCN1CC2=CC=C(C3=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C3)C=C2.Cl. InChi Code: InChI=1S/C22H22F6N2O2.ClH/c1-15(31)30-12-10-29(11-13-30)14-16-2-4-17(5-3-16)18-6-8-19(9-7-18)20(32,21(23,24)25)22(26,27)28,/h2-9,32H,10-14H2,1H3,1H. InChi Key: OHUOFZJUUXXRGG-UHFFFAOYSA-N. License: Sold under license from The Scripps Research Institute..