Skyrin

Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor. At 10 µM, skyrin reduces both glucagon-stimulated cAMP production and glycogenolysis. It does not interfere with epinephrine or glucagon-like peptide 1 effects on these parameters.Formal Name: 2,2',4,4',5,5'-hexahydroxy-7,7'-dimethyl-[1S,1'-bianthracene]-9,9',10,10'-tetrone. CAS Number: 602-06-2. Synonyms: Endothianin, Rhodophyscin. Molecular Formula: C30H18O10. Formula Weight: 538.5. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: CC1=CC(O)=C2C(C(C(C(C3=C(O)C=C(O)C(C(C4=C5C=C(C)C=C4O)=O)=C3C5=O)=C(O)C=C6O)=C6C2=O)=O)=C1. InChi Code: InChI=1S/C30H18O10/c1-9-3-11-19(13(31)5-9)29(39)23-17(35)7-15(33)21(25(23)27(11)37)22-16(34)8-18(36)24-26(22)28(38)12-4-10(2)6-14(32)20(12)30(24)40/h3-8,31-36H,1-2H3. InChi Key: MQSXZQXHIJMNAF-UHFFFAOYSA-N. Origin: Fungus/Penicillium sp..