SKPin C1

SKPin C1 is an inhibitor of Skp1-Cullin1-F-box (SCF) family protein Skp2-mediated p27 degradation. It binds to Skp2 at the Cdc kinase subunit 1 (Cks1) interaction interface and blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro when used at a concentration of 50 µM. SKPin C1 increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells.Formal Name: 2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]-acetic acid. CAS Number: 432001-69-9. Molecular Formula: C18H13BrN2O4S2. Formula Weight: 465.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/mL. lambdamax: 389 nm. SMILES: BrC1=CC=C(OCC(O)=O)C(/C=C2C(N(CC3=CC=CN=C3)C(S\2)=S)=O)=C1. InChi Code: InChI=1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7+. InChi Key: IYCJJVVXEHZJHE-VIZOYTHASA-N.