SB 222200

SB 222200 is a neurokinin-3 (NK3) receptor antagonist (IC50 = 18.4 nM). It is selective for NK3 over NK1 and NK2 receptors (IC50s = 250 and >100,000 nM, respectively). SB 222200 decreases calcium mobilization induced by neurokinin B (Cay-24542) with an IC50 value of 265 nM in HEK293 cells expressing the recombinant human receptor. It inhibits contractions induced by senktide (Cay-16721) in isolated rabbit iris sphincter muscle when used at a concentration of 300 nM. SB 222200 (500 pmol, i.c.v.) decreases mean arterial pressure in spontaneously hypertensive, but not normotensive, rats. It prevents senktide-induced head shakes and tail whips in mice (ED50 = 5.6 mg/kg).Formal Name: 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide. CAS Number: 174635-69-9. Molecular Formula: C26H24N2O. Formula Weight: 380.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/mL, DMSO: 10mg/mL, Ethanol: 15mg/mL, Ethanol:PBS (pH 7.2) (1:2): 0.3mg/mL. lambdamax: 232 nm. SMILES: CC[C@H](NC(C1=C(C)C(C2=CC=CC=C2)=NC3=C1C=CC=C3)=O)C4=CC=CC=C4. InChi Code: InChI=1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1. InChi Key: MQNYRKWJSMQECI-QFIPXVFZSA-N.