S-ethyl N-[4-(trifluoromethyl)phenyl] Isothiourea (hydrochloride)

EPIT is a selective, competitive inhibitor of nNOS having a Ki of 0.32 µM for the purified human enzyme. EPIT exhibits 115-fold and 29-fold selectivity for nNOS compared to iNOS and eNOS, respectively. It exhibits reduced inhibitory potency in whole-cell assays, possibly due to reduced intracellular uptake.Formal Name: N-[4-(trifluoromethyl)phenyl]-carbamimidothioic acid, ethyl ester, monohydrochloride. CAS Number: 163490-78-6. Synonyms: EPIT. Molecular Formula: C10H11F3N2S . HCl. Formula Weight: 284.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: >54 mg/ml, DMSO: >33.6 mg/ml, Ethanol: >55 mg/ml, Ethanol:PBS (pH 7.2) 1:3: 1 mg/ml, PBS pH 7.2: <50 µg/ml, Water: 50 mg/ml. lambdamax: 245 nm. SMILES: CCS/C(N([H])C1=CC=C(C(F)(F)F)C=C1)=N\[H].Cl. InChi Code: InChI=1S/C10H11F3N2S.ClH/c1-2-16-9(14)15-8-5-3-7(4-6-8)10(11,12)13,/h3-6H,2H2,1H3,(H2,14,15),1H. InChi Key: UVJQIYZYQQKIAC-UHFFFAOYSA-N.