Zu "K13240" wurden 110 Artikel gefunden!
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(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride)
Artikelnummer: Cay81880-100
(6R)-5,6,7,8-tetrahydro-L-Biopterin (hydrochloride) (BH4) is a cofactor that, in the presence of enzyme site iron, binds to phenylalanine hydroxylase, tryptophan or tyrosine hydroxylase, and nitric oxide synthase (NOS), to facilitate the production of aromatic amino acids, neurotransmitters, and nitric oxide (NO),...
| Schlagworte: | BH4, 2-amino-6R-(1R,2S-dihydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone, dihydrochloride |
| Anwendung: | NOS cofactor |
| CAS | 69056-38-8 |
| MW: | 314.2 D |
ab 62,00 €
Anti-nNOS
Artikelnummer: Cay160870-1
Nitric oxide synthase (NOS) catalyzes the oxidation of arginine to nitric oxide (NO) and citrulline. Three distinct isoforms of NOS have been described having nomenclature based on the tissue source from which they were originally cloned. These three isoforms are neuronal/brain NOS (nNOS/bNOS/NOS-I), inducible NOS...
| Schlagworte: | Anti-NOS1, Anti-nNOS, Anti-bNOS, Anti-nNOS, Anti-bNOS, Anti-N-NOS, Anti-N-NOS, Anti-NC-NOS, Anti-NC-NOS, Anti-NOS type I,... |
| Anwendung: | ICC, IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
483,00 €
L-NIO (hydrochloride)
Artikelnummer: Cay80320-100
L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 µM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.Formal...
| Schlagworte: | N5-(1-iminoethyl)-L-ornithine, dihydrochloride |
| Anwendung: | NOS inhibitor |
| CAS | 36889-13-1 |
| MW: | 246.1 D |
ab 28,00 €
L-NMMA (acetate)
Artikelnummer: Cay10005031-100
L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared. It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.Formal Name:...
| Schlagworte: | L-NG-monomethyl Arginine acetate, N5-[imino(methylamino)methyl]-L-ornithine, monoacetate |
| Anwendung: | NOS inhibitor |
| CAS | 53308-83-1 |
| MW: | 248.3 D |
ab 28,00 €
L-NMMA (citrate)
Artikelnummer: Cay80200-10
L-NMMA is a relatively non-selective inhibitor of all NOS isoforms. It is the archetypal NOS inhibitor to which other inhibitors are most often compared. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.Formal Name:...
| Schlagworte: | L-NG-monomethyl Arginine citrate, N5-[imino(methylamino)methyl]-L-ornithine, citrate |
| Anwendung: | NOS inhibitor |
| MW: | 756.8 D |
ab 59,00 €
S-methyl-L-Thiocitrulline (hydrochloride)
Artikelnummer: Cay80585-10
S-methyl-L-Thiocitrulline is a potent NOS inhibitor with selectivity toward the neuronal isoform compared to eNOS and iNOS. For human enzymes, it exhibits Ki values of 1.2, 11, and 40 nM for nNOS, eNOS, and iNOS, respectively.Formal Name: N5-[imino(methylthio)methyl]-L-ornithine, dihydrochloride. CAS Number:...
| Schlagworte: | methyl-TC, SMTC, N5-[imino(methylthio)methyl]-L-ornithine, dihydrochloride |
| Anwendung: | NOS inhibitor |
| CAS | 209589-59-3 |
| MW: | 278.2 D |
ab 57,00 €
NG-amino-L-Arginine (hydrochloride)
Artikelnummer: Cay10554-5
NG-amino-L-Arginine inhibits nNOS, iNOS, and eNOS with Ki values of 0.3, 3, and 2.5 µM, respectively. Inhibition is mediated by covalent alteration of the heme prosthetic group leading to inactivation of the enzyme. NG-amino-L-Arginine can be used both in cell culture and in vivo.Formal Name:...
| Schlagworte: | N5-(hydrazinyliminomethyl)-L-ornithine, monohydrochloride |
| Anwendung: | NOS inhibitor |
| CAS | 1031799-40-2 |
| MW: | 225.7 D |
ab 83,00 €
L-NNA
Artikelnummer: Cay80220-1
L-NNA is a competitive inhibitor of nitric oxide synthase (NOS) with selectivity for the neuronal and endothelial isoforms of the enzyme. Although L-NAME is much more soluble than L-NNA in aqueous systems, a hydrolysis step is required to "activate" L-NAME, thus adding complexity to an in vivo experiment. L-NNA...
| Schlagworte: | L-NG-Nitroarginine, NG-nitro-L-Arginine, N5-[imino(nitroamino)methyl]-L-ornithine |
| Anwendung: | NOS inhibitor |
| CAS | 2149-70-4 |
| MW: | 219.2 D |
ab 24,00 €
Vinyl-L-NIO (hydrochloride)
Artikelnummer: Cay80330-10
Vinyl-L-NIO is a potent, selective inhibitor of nNOS. The Ki values for inhibition of nNOS, eNOS, and iNOS by vinyl-L-NIO are 100 nM, 12 and 60 µM, respectively, as determined using initial rate measurements. In the presence of NADPH and O2, vinyl-L-NIO irreversibly inactivates nNOS with a kinact of 0.078 min-1 and...
| Schlagworte: | N5-(1-imino-3-butenyl)-L-ornithine, monohydrochloride |
| Anwendung: | nNOS inhibitor |
| CAS | 728944-69-2 |
| MW: | 235.7 D |
ab 85,00 €
Nomega-propyl-L-Arginine
Artikelnummer: Cay80587-5
Nomega-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). Nomega-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a Ki value of 57 nM. The Ki values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 µM, respectively. Nomega-propyl-L-Arginine therefore...
| Schlagworte: | N5-[imino(propylamino)methyl]-L-ornithine |
| Anwendung: | nNOS inhibitor |
| CAS | 137361-05-8 |
| MW: | 216.3 D |
ab 85,00 €
7-Nitroindazole
Artikelnummer: Cay81340-100
7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 µM, respectively.Formal Name:...
| Schlagworte: | 7-nitro-1H-indazole |
| Anwendung: | NOS inhibitor |
| CAS | 2942-42-9 |
| MW: | 163.1 D |
ab 51,00 €
2-Iminobiotin
Artikelnummer: Cay20812-100
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS, Kis = 21.8 and 37.5 µM for mouse iNOS and rat nNOS, respectively). It also provides sex-specific neuroprotection against hypoxia-ischemia in neonatal rats by an...
| Schlagworte: | Guanidinobiotin, (3aR,6S,6aS)-2-amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazole-6-pentanoic acid |
| Anwendung: | iNOS / nNOS inhibitor |
| CAS | 13395-35-2 |
| MW: | 243.3 D |
ab 51,00 €