S-72

S-72 is an inhibitor of microtubule polymerization. It inhibits microtubule polymerization in a cell-free assay when used at concentrations 1, 3, and 10 µM. S-72 reduces viability in MCF-7 and paclitaxel-resistant MCF-7/T breast cancer cells (IC50s = 15.64 and 26.32 nM, respectively). It inhibits migration and invasion, as well as the percentage of wound closure in a scratch assay, in MCF-7 and MCF-7/T cells when used at a concentration of 50 nM. S-72 (100 nM) induces cell cycle arrest at the G2/M phase in MCF-7/T cells, as well as induces apoptosis in those same cells. It also inhibits stimulator of interferon genes (STING) activation in MCF-7/T cells when used at a concentration of 100 nM. S-72 (15 mg/kg per day) inhibits tumor growth in MCF-7/T and MX-1/T mouse xenograft models of paclitaxel-resistant breast cancer.Formal Name: 4-methyl-3-[[(4-methylphenyl)sulfonyl]amino]-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-benzamide. CAS Number: 2446799-14-8. Molecular Formula: C20H22N4O3S. Formula Weight: 398.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 30 mg/ml. SMILES: O=[S](NC1=CC(C(NCC(C=N2)=CN2C)=O)=CC=C1C)(C(C=C3)=CC=C3C)=O. InChi Code: InChI=1S/C20H22N4O3S/c1-14-4-8-18(9-5-14)28(26,27)23-19-10-17(7-6-15(19)2)20(25)21-11-16-12-22-24(3)13-16/h4-10,12-13,23H,11H2,1-3H3,(H,21,25). InChi Key: GDFZUYYZZBJRBP-UHFFFAOYSA-N.