RI-2

RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 µM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types. At 150 µM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro.Formal Name: 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione. CAS Number: 1417162-36-7. Molecular Formula: C21H18Cl2N2O4. Formula Weight: 433.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 2 mg/ml. lambdamax: 264, 412 nm. SMILES: O=C(N1C2=CC(Cl)=C(Cl)C=C2)C(C3=CC=C(OC)C=C3)=C(N4CCOCC4)C1=O. InChi Code: InChI=1S/C21H18Cl2N2O4/c1-28-15-5-2-13(3-6-15)18-19(24-8-10-29-11-9-24)21(27)25(20(18)26)14-4-7-16(22)17(23)12-14/h2-7,12H,8-11H2,1H3. InChi Key: JMPJNNOSVCHYOU-UHFFFAOYSA-N.