Ramosetron (hydrochloride)

Ramosetron is a potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM). It has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors. Ramosetron competitively blocks serotonin-mediated contraction of the colon. It has applications in ameliorating diarrhea-predominant inflammatory bowel syndrome and postoperative nausea and vomiting.Formal Name: (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-methanone, monohydrochloride. CAS Number: 132907-72-3. Molecular Formula: C17H17N3O . HCl. Formula Weight: 315.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 0.1 mg/ml. lambdamax: 212, 244, 306 nm. SMILES: O=C(C1=CN(C)C2=C1C=CC=C2)[C@@H]3CCC4=C(NC=N4)C3.Cl. InChi Code: InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14,/h2-5,9-11H,6-8H2,1H3,(H,18,19),1H/t11-,/m1./s1. InChi Key: XIXYTCLDXQRHJO-RFVHGSKJSA-N.