Phthalazinone pyrazole

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 µM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 µM, respectively).Formal Name: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1(2H)-phthalazinone. CAS Number: 880487-62-7. Molecular Formula: C18H15N5O. Formula Weight: 317.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.25 mg/ml, DMSO: 0.15 mg/ml. lambdamax: 331 nm. SMILES: O=C1C2=C(C=CC=C2)C(NC3=NNC(C)=C3)=NN1C4=CC=CC=C4. InChi Code: InChI=1S/C18H15N5O/c1-12-11-16(21-20-12)19-17-14-9-5-6-10-15(14)18(24)23(22-17)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22). InChi Key: DSDIWWSXOOXFSI-UHFFFAOYSA-N.