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Zu "K11481" wurden 118 Artikel gefunden!
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Artikelnummer: BPS-82095
The Chemi-Verse(TM) Aurora Kinase A Assay Kit is a luminescence assay designed to measure Aurora Kinase A activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant Aurora Kinase A, kinase substrate,...
Schlagworte: | ARK-1, Aurora 2, Aurora kinase A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase,... |
Anwendung: | Enzyme kinetics, kinase assay, small molecule inhibitor screening, drug discovery, HTS |
Spezies-Reaktivität: | human |
1.101,00 €
Artikelnummer: Cay10735-1
Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not...
Schlagworte: | 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone |
CAS | 880487-62-7 |
MW: | 317.4 D |
ab 92,00 €
Artikelnummer: NSJ-RQ7272
0.5mg/ml if reconstituted with 0.2ml sterile DI water. AURKA (Aurora kinase A), also called ARK1, AurA, AIK , AURORA2, BTAK, PPP1R47, STK7, STK15, STK6, is a mitotic centrosomal protein kinase. The main role of STK15 in tumor development is in controlling chromosome segregation during mitosis. It is a member of a...
Schlagworte: | Anti-ARK-1, Anti-Aurora 2, Anti-Aurora kinase A, Anti-Aurora-related kinase 1, Anti-Aurora/IPL1-related kinase 1,... |
Anwendung: | WB, IHC (paraffin), FC, Direct ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: NSJ-RQ7273
0.5mg/ml if reconstituted with 0.2ml sterile DI water. AURKA (Aurora kinase A), also called ARK-1 (Aurora-related kinase 1), AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15, and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA/ARK-1 in tumor development is in controlling chromosome segregation...
Schlagworte: | Anti-Aurka, Anti-ARK-1, Anti-Aurora 2, Anti-Aurora kinase A, Anti-Aurora-related kinase 1, Anti-Aurora/IPL1-related kinase... |
Anwendung: | WB, Direct ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | mouse, rat |
755,00 €
Artikelnummer: Cay13602-1
MLN8237 is an inhibitor of Aurora A kinase (IC50 = 1 nM). It is selective for Aurora A over Aurora B kinase (IC50 = 396.5 nM). MLN8237 (50 nM) induces cell cycle arrest at the G2/M phase and chromosomal misalignment in HCT116 colon cancer cells. It inhibits tumor growth in a Calu-6 non-small cell lung cancer (NSCLC)...
Schlagworte: | Alisertib, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy benzoic acid |
Anwendung: | Aurora A kinase inhibitor |
CAS | 1028486-01-2 |
MW: | 518.9 D |
ab 43,00 €
Artikelnummer: LKT-M4652.10
MLN8237 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MLN8237 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for multiple myeloma, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia (CLL). In...
Schlagworte: | Alisertib |
Anwendung: | Aurora A kinase inhibitor |
CAS | 1028486-01-2 |
MW: | 518.92 D |
ab 156,00 €
Artikelnummer: A300-071A
Protein function: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication,...
Schlagworte: | Anti-AIK, Anti-AURKA, Anti-ARK-1, Anti-hARK1, Anti-Aurora 2, EC=2.7.11.1, Anti-Aurora kinase A, Anti-Aurora-related kinase... |
Anwendung: | WB, IP |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 164,00 €
Artikelnummer: BPS-40004
Active human Aurora kinase A (GenBank Accession No. NM_003600), (a.a. 2- 403) with N-terminal HIS6 tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: | ARK-1, Aurora 2, Aurora kinase A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase,... |
Anwendung: | Enzyme kinetics, inhibitor screening |
MW: | 50 kD |
525,00 €
Artikelnummer: Cay11496-5
AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential...
Schlagworte: | N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-urea |
Anwendung: | Broad spectrum kinase inhibitor |
CAS | 896466-04-9 |
MW: | 381.4 D |
ab 113,00 €
Artikelnummer: Cay21600-5
Aurora A inhibitor I is a potent and selective inhibitor of Aurora A kinase (IC50s = 3.4 and 3,400 nM for Aurora A and Aurora B, respectively). It prevents centrosome separation and reduces phosphorylated Aurora A, but not phosphorylated histone H3, levels at the centrosomes, indicating inhibition is specific to...
Schlagworte: | N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide |
Anwendung: | AURKA inhibitor |
CAS | 1158838-45-9 |
MW: | 588.1 D |
ab 43,00 €
Artikelnummer: Cay14974-1
SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively). In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM). SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma...
Schlagworte: | N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-urea, monomethanesulfonate |
Anwendung: | Aurora kinase inhibitor |
CAS | 1146618-41-8 |
MW: | 527 D |
ab 109,00 €
Artikelnummer: Cay18387-5
Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...
Schlagworte: | PHA-739358,... |
Anwendung: | Aurora kinase inhibitor |
CAS | 827318-97-8 |
MW: | 474.6 D |
ab 60,00 €