Zu "K11481" wurden 118 Artikel gefunden!

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Chemi-Verse(TM) Aurora Kinase A Assay Kit
Chemi-Verse(TM) Aurora Kinase A Assay Kit

Artikelnummer: BPS-82095

The Chemi-Verse(TM) Aurora Kinase A Assay Kit is a luminescence assay designed to measure Aurora Kinase A activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant Aurora Kinase A, kinase substrate,...
Schlagworte: ARK-1, Aurora 2, Aurora kinase A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase,...
Anwendung: Enzyme kinetics, kinase assay, small molecule inhibitor screening, drug discovery, HTS
Spezies-Reaktivität: human
1.101,00 €
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Phthalazinone pyrazole
Phthalazinone pyrazole

Artikelnummer: Cay10735-1

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not...
Schlagworte: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone
CAS 880487-62-7
MW: 317.4 D
ab 92,00 €
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Anti-STK15 / Serine/threonine-protein kinase 15 / AURKA
Anti-STK15 / Serine/threonine-protein kinase 15 / AURKA

Artikelnummer: NSJ-RQ7272

0.5mg/ml if reconstituted with 0.2ml sterile DI water. AURKA (Aurora kinase A), also called ARK1, AurA, AIK , AURORA2, BTAK, PPP1R47, STK7, STK15, STK6, is a mitotic centrosomal protein kinase. The main role of STK15 in tumor development is in controlling chromosome segregation during mitosis. It is a member of a...
Schlagworte: Anti-ARK-1, Anti-Aurora 2, Anti-Aurora kinase A, Anti-Aurora-related kinase 1, Anti-Aurora/IPL1-related kinase 1,...
Anwendung: WB, IHC (paraffin), FC, Direct ELISA
Wirt: Rabbit
Spezies-Reaktivität: human
755,00 €
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Anti-Ark-1 / Aurora-related kinase 1 / Aurka
Anti-Ark-1 / Aurora-related kinase 1 / Aurka

Artikelnummer: NSJ-RQ7273

0.5mg/ml if reconstituted with 0.2ml sterile DI water. AURKA (Aurora kinase A), also called ARK-1 (Aurora-related kinase 1), AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15, and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA/ARK-1 in tumor development is in controlling chromosome segregation...
Schlagworte: Anti-Aurka, Anti-ARK-1, Anti-Aurora 2, Anti-Aurora kinase A, Anti-Aurora-related kinase 1, Anti-Aurora/IPL1-related kinase...
Anwendung: WB, Direct ELISA
Wirt: Rabbit
Spezies-Reaktivität: mouse, rat
755,00 €
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MLN8237
MLN8237

Artikelnummer: Cay13602-1

MLN8237 is an inhibitor of Aurora A kinase (IC50 = 1 nM). It is selective for Aurora A over Aurora B kinase (IC50 = 396.5 nM). MLN8237 (50 nM) induces cell cycle arrest at the G2/M phase and chromosomal misalignment in HCT116 colon cancer cells. It inhibits tumor growth in a Calu-6 non-small cell lung cancer (NSCLC)...
Schlagworte: Alisertib, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy benzoic acid
Anwendung: Aurora A kinase inhibitor
CAS 1028486-01-2
MW: 518.9 D
ab 43,00 €
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MLN8237
MLN8237

Artikelnummer: LKT-M4652.10

MLN8237 inhibits aurora kinase A (AurA) preventing mitotic spindle formation and proper completion of mitosis. MLN8237 exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for multiple myeloma, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia (CLL). In...
Schlagworte: Alisertib
Anwendung: Aurora A kinase inhibitor
CAS 1028486-01-2
MW: 518.92 D
ab 156,00 €
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Anti-Aurora A
Anti-Aurora A

Artikelnummer: A300-071A

Protein function: Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication,...
Schlagworte: Anti-AIK, Anti-AURKA, Anti-ARK-1, Anti-hARK1, Anti-Aurora 2, EC=2.7.11.1, Anti-Aurora kinase A, Anti-Aurora-related kinase...
Anwendung: WB, IP
Wirt: Rabbit
Spezies-Reaktivität: human
ab 164,00 €
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Aurora Kinase A, active human recombinant protein
Aurora Kinase A, active human recombinant protein

Artikelnummer: BPS-40004

Active human Aurora kinase A (GenBank Accession No. NM_003600), (a.a. 2- 403) with N-terminal HIS6 tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: ARK-1, Aurora 2, Aurora kinase A, Aurora-related kinase 1, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase,...
Anwendung: Enzyme kinetics, inhibitor screening
MW: 50 kD
525,00 €
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AT-9283
AT-9283

Artikelnummer: Cay11496-5

AT-9283 is a broad spectrum kinase inhibitor that potently inhibits Aurora A, Aurora B, JAK2, JAK3, and c-ABL (IC50s = 3, 3, 1.2, 1.1, and 4 nM, respectively). It also potently (IC50 = receptor tyrosine kinases. As Aurora kinases have roles in mitosis, inhibitors of these kinases, including AT-9283, have potential...
Schlagworte: N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-urea
Anwendung: Broad spectrum kinase inhibitor
CAS 896466-04-9
MW: 381.4 D
ab 113,00 €
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Aurora A Inhibitor I
Aurora A Inhibitor I

Artikelnummer: Cay21600-5

Aurora A inhibitor I is a potent and selective inhibitor of Aurora A kinase (IC50s = 3.4 and 3,400 nM for Aurora A and Aurora B, respectively). It prevents centrosome separation and reduces phosphorylated Aurora A, but not phosphorylated histone H3, levels at the centrosomes, indicating inhibition is specific to...
Schlagworte: N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
Anwendung: AURKA inhibitor
CAS 1158838-45-9
MW: 588.1 D
ab 43,00 €
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SNS-314 (mesylate)
SNS-314 (mesylate)

Artikelnummer: Cay14974-1

SNS-314 is a pan-Aurora kinase inhibitor (IC50s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively). In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50s = 5-100 nM). SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma...
Schlagworte: N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-urea, monomethanesulfonate
Anwendung: Aurora kinase inhibitor
CAS 1146618-41-8
MW: 527 D
ab 109,00 €
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Danusertib
Danusertib

Artikelnummer: Cay18387-5

Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...
Schlagworte: PHA-739358,...
Anwendung: Aurora kinase inhibitor
CAS 827318-97-8
MW: 474.6 D
ab 60,00 €
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