PD 166866

PD 166866 is a potent inhibitor of fibroblast growth factor receptor 1 (FGFR1, IC50 = 52.4 nM, Ki = 45.2 nM). It is selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 µM). PD 166866 inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively) and inhibits phosphorylation of MAPK (IC50s = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively). It reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro. PD 166866 inhibits the growth of non-small cell lung cancer (NSCLC) cell lines in a dose-dependent manner and reduces migration of VL-8 cells at a concentration of 10 µM.Formal Name: N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea. CAS Number: 192705-79-6. Molecular Formula: C20H24N6O3. Formula Weight: 396.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 232, 365 nm. SMILES: NC1=NC=C(C=C(C2=CC(OC)=CC(OC)=C2)C(NC(NC(C)(C)C)=O)=N3)C3=N1. InChi Code: InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27). InChi Key: NHJSWORVNIOXIT-UHFFFAOYSA-N.