Zu "K04362" wurden 208 Artikel gefunden!
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FGFR1, active human recombinant protein
Artikelnummer: BPS-40210
Active recombinant human FGFR1 (399-822) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag. The gene accession number is NM_023110. Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
| Schlagworte: | N-sam, CD331, BFGFR, FLT-2, FGFR1, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fibroblast growth... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 73 kD |
901,00 €
Anti-FGFR1/CD331 Monoclonal Antibody
Artikelnummer: E-AN200107P.100
FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10...
| Schlagworte: | FLT-2, N-sam, CD331, BFGFR, FGFR1, FGFR-1, bFGF-R-1, Proto-oncogene c-Fgr, Fms-like tyrosine kinase 2, Fibroblast growth... |
| Anwendung: | IHC (paraffin) |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
389,00 €
CH5183284
Artikelnummer: Cay17120-1
CH5183284 is a potent, selective inhibitor of the kinase activity of fibroblast growth factor receptors (FGFRs) 1, 2, and 3 (IC50s = 9.3, 7.6, and 22 nM, respectively). It less potently inhibits FGFR4 and platelet-derived growth factor receptor beta (IC50s = 290 and 560 nM, respectively) and displays IC50 values...
| Schlagworte: | Debio 1347, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl-methanone |
| Anwendung: | FGFR1/2/3 inhibitor |
| CAS | 1265229-25-1 |
| MW: | 356.4 D |
ab 73,00 €
TAS 120
Artikelnummer: Cay21136-1
TAS 120 is an orally bioavailable inhibitor of fibroblast growth factor receptors (FGFRs) that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations. It prevents phosphorylation of FGFRs and impedes downstream signaling pathways in cells. TAS 120 blocks the proliferation of human cancer cell lines...
| Schlagworte: | 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one |
| Anwendung: | FGFR inhibitor |
| CAS | 1448169-71-8 |
| MW: | 418.5 D |
ab 85,00 €
SU 5402
Artikelnummer: Cay13182-10
SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRbeta (IC50s = 0.02, 0.03, and 0.51 µM, respectively). It is much less effective against other receptor tyrosine kinases. SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.Formal Name:...
| Schlagworte: | 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid |
| Anwendung: | FGFR1 /?VEGFR2 inhibitor |
| CAS | 215543-92-3 |
| MW: | 296.3 D |
ab 42,00 €
Pemigatinib
Artikelnummer: Cay33260-5
Pemigatinib is an inhibitor of FGFR (IC50s = 0.4, 0.5, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively). It is selective for FGFR1, FGFR2, and FGFR3 over FGFR4 and the kinase insert domain receptor (KDR, IC50s = 30 and 70 nM, respectively), as well as over a panel of 56 tyrosine and serine/threonine kinases at 10...
| Schlagworte: | INCB054828,... |
| Anwendung: | FGFR inhibitor |
| CAS | 1513857-77-6 |
| MW: | 487.5 D |
ab 72,00 €
Nintedanib
Artikelnummer: TGM-T1777-200mg
Description: Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRalpha, and PDGFRbeta (IC50=59/65 nM). Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis....
| Schlagworte: | BIBF 1120, Intedanib |
| Anwendung: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| CAS | 656247-17-5 |
| MW: | 539.62 D |
ab 37,00 €
Lenvatinib
Artikelnummer: Cay19375-1
Lenvatinib is an inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and VEGFR3 (IC50s = 4 and 5.2 nM, respectively). It also inhibits the related kinases VEGFR1, FGFR1, PDGFRalpha, PDGFRbeta and Kit (IC50s = 22, 46, 51, 39, and 100 nM, respectively). Lenvatinib (30 mg/kg, twice per day) reduces...
| Schlagworte: | E-7080, ER-203492-00, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide |
| Anwendung: | VEGFR / FGFR / PDGFR inhibitor |
| CAS | 417716-92-8 |
| MW: | 426.9 D |
ab 49,00 €
PD 166866
Artikelnummer: Cay22464-5
PD 166866 is a potent inhibitor of fibroblast growth factor receptor 1 (FGFR1, IC50 = 52.4 nM, Ki = 45.2 nM). It is selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 µM). PD 166866 inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and...
| Schlagworte: | N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
| Anwendung: | FGFR1 inhibitor |
| CAS | 192705-79-6 |
| MW: | 396.4 D |
ab 49,00 €
JNJ-42756493
Artikelnummer: Cay21813-10
JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...
| Schlagworte: | Erdafitinib, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-[3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl]-1,2-ethanediamine |
| Anwendung: | FGFR inhibitor |
| CAS | 1346242-81-6 |
| MW: | 446.6 D |
ab 48,00 €
Dovitinib
Artikelnummer: Cay15220-5
Dovitinib is a multi-kinase inhibitor. It inhibits the receptor tyrosine kinases FLT3, CSF1R, and c-Kit (IC50s = 1, 36, and 2 nM, respectively), as well as FGFR1, FGFR3, VEGFR1-3, PDFGRalpha, and PDGFRbeta (IC50s = 8, 9, 10, 13, 8, 27, and 210 nM, respectively). Dovitinib inhibits proliferation of human multiple...
| Schlagworte: | CHIR-258, TKI-258, 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone |
| Anwendung: | PDGFRB / VEGFR2 / FGFR1 inhibitor |
| CAS | 405169-16-6 |
| MW: | 392.4 D |
ab 181,00 €
Anti-FGFR1
Artikelnummer: NSJ-F50611-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a...
| Schlagworte: | Anti-FLT-2, Anti-CD331, Anti-FGFR1, Anti-BFGFR, Anti-N-sam, Anti-FGFR-1, Anti-bFGF-R-1, Anti-Proto-oncogene c-Fgr,... |
| Anwendung: | IHC, IF, FC, WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 361,00 €