Oxybutynin (hydrochloride)

Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1 nM, respectively). Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID50s = 0.062 and 0.089 mg/kg, respectively). It also increases pupil diameter (PD) and locomotor activity (LMA, ED50s = 0.29 and 0.52 mg/kg, respectively) and decreases small intestinal transit (SIT, ID50 = 0.22 mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder.Formal Name: 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride. CAS Number: 1508-65-2. Synonyms: MJ4309-1. Molecular Formula: C22H31NO3 . HCl. Formula Weight: 394.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 0.2 mg/ml. lambdamax: 202 nm. SMILES: OC(C1CCCCC1)(C(OCC#CCN(CC)CC)=O)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20,/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3,1H. InChi Key: SWIJYDAEGSIQPZ-UHFFFAOYSA-N.