Zu "K04130" wurden 92 Artikel gefunden!
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Metixene (hydrochloride hydrate)
Artikelnummer: Cay39825-1
Metixene is an antagonist of muscarinic acetylcholine receptors (mAChRs, Ki = 15 nM for the rat receptor). It also inhibits bovine acetylcholinesterase (AChE) by 43% when used at the concentration 10 µM and butyrylcholinesterase (BChE, IC50 = 1.6 µM for the horse enzyme) in cell-free assays. Metixene reduces the...
| Schlagworte: | Methixine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-piperidine, monohydrochloride, monohydrate |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 7081-40-5 |
| MW: | 363.9 D |
ab 34,00 €
Atropine
Artikelnummer: Cay32997-1
Atropine (Cay-32997) is an analytical reference standard categorized as an antagonist of muscarinic acetylcholine receptors (mAChRs). Atropine has been found as an adulterant in cocaine. This product is intended for analytical forensic applications. This product is also available as a general research tool...
| Schlagworte: | DL-Hyoscyamine, Tropine tropate, benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl... |
| Anwendung: | Analytical reference standard, mAChR antagonist, cocaine aldulterant |
| CAS | 51-55-8 |
| MW: | 289.4 D |
ab 98,00 €
Atropine
Artikelnummer: Cay12008-1
Atropine is a naturally occurring tropane alkaloid extracted from plants of the family Solanaceae including deadly nightshade (A. belladonna). It is a non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8). Atropine increases firing of...
| Schlagworte: | DL-Hyoscyamine, Tropine tropate, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester-benzeneacetic acid |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 51-55-8 |
| MW: | 289.4 D |
ab 34,00 €
(+)-Pilocarpine (hydrochloride)
Artikelnummer: Cay14487-500
(+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (apparent Kis = 6, 8.2, and 6.9 µM, respectively). It induces salivary secretion in rats when...
| Schlagworte: | NSC 5746, (3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 54-71-7 |
| MW: | 244.7 D |
ab 50,00 €
Oxotremorine M (iodide)
Artikelnummer: Cay20847-50
Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 µM, respectively). It also increases M4-induced inhibition of calcium currents in...
| Schlagworte: | N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium, monoiodide |
| Anwendung: | Muscarinic receptor agonist |
| CAS | 3854-04-4 |
| MW: | 322.2 D |
ab 97,00 €
Bethanechol (chloride)
Artikelnummer: Cay23830-1
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated...
| Schlagworte: | (±)-Bethanechol, Carbamyl-beta-methylcholine chloride, NSC 30783, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium,... |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 590-63-6 |
| MW: | 196.7 D |
ab 50,00 €
Oxybutynin (hydrochloride)
Artikelnummer: Cay23825-1
Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from...
| Schlagworte: | MJ4309-1, 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 1508-65-2 |
| MW: | 394 D |
ab 98,00 €
Methoctramine (hydrate)
Artikelnummer: Cay24317-10
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes). It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea...
| Schlagworte: | N1,N8-bis[6-[[(2-methoxyphenyl)methyl]amino]hexyl]-1,8-octanediamine, tetrahydrochloride, hydrate |
| Anwendung: | Selective M2 muscarinic acetylcholine receptor antagonist |
| MW: | 728.8 D |
ab 156,00 €
Dicyclomine (hydrochloride)
Artikelnummer: Cay23867-500
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol, Cay-14486) in guinea pig cortex (Ki = 12 nM, pA2 = 7.88). Dicyclomine (10 mg/kg,...
| Schlagworte: | Dicycloverine, [1,1'-bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride |
| Anwendung: | Muscarinic acetylcholine receptor M1 / M2 antagonist |
| CAS | 67-92-5 |
| MW: | 346 D |
ab 27,00 €
Umeclidinium (bromide)
Artikelnummer: Cay20700-10
Umeclidinium is an antagonist of muscarinic acetylcholine receptors (Kis = 0.05-0.16 nM for M1-M5 human recombinant receptors). It inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM) and bronchoconstriction in mice when administered intranasally (ED50 =...
| Schlagworte: | GSK573719, 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octane, monobromide |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 869113-09-7 |
| MW: | 508.5 D |
ab 163,00 €
(-)-Hyoscyamine
Artikelnummer: Cay25644-250
(-)-Hyoscyamine is a tropane alkaloid, a muscarinic receptor antagonist, and an isomer of atropine (Cay-12008). (-)-Hyoscyamine inhibits the arterial depressor response induced by the muscarinic agonist methacholine in dogs. It is more effective than atropine at inhibiting EEG arousal in dogs following sciatic nerve...
| Schlagworte: | (S)-Hyoscyamine, L-Hyoscyamine, (alphaS)-alpha-(hydroxymethyl)-benzeneacetic acid,... |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 101-31-5 |
| MW: | 289.4 D |
ab 43,00 €
LY2119620
Artikelnummer: Cay26373-5
LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 µM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh, Cay-23829) and the mAChR agonists...
| Schlagworte: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide |
| Anwendung: | Muscarinic acetylcholine receptor M2 / M4 positive allosteric modulator (PAM) |
| CAS | 886047-22-9 |
| MW: | 437.9 D |
ab 98,00 €