Zu "K04130" wurden 101 Artikel gefunden!
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Anti-Muscarinic acetylcholine receptor M2, Human, mAb B8E5
Artikelnummer: HYC-HM2239-100UG
For immunohistology, and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's...
| Schlagworte: | Anti-CHRM2, Anti-Muscarinic acetylcholine receptor M2 |
| Anwendung: | IHC-F, FA, ELISA, IF, WB |
| Spezies-Reaktivität: | human |
ab 139,00 €
Anti-Recombinant Muscarinic Acetylcholine Receptor 2/CM2,...
Artikelnummer: E-AN301426L.100
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C...
| Schlagworte: | Anti-CHRM2, Anti-Muscarinic acetylcholine receptor M2, Recombinant Muscarinic Acetylcholine Receptor 2/CM2 Monoclonal... |
| Anwendung: | WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, rat, mouse |
ab 304,00 €
CHO-K1/M2/Galpha15 Stable Cell Line
Artikelnummer: GSC-M00258
Recombinant CHO-K1 cells stably overexpress human cholinergic receptor muscarinic 2 (M2) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.
| Schlagworte: | CHRM2, Muscarinic acetylcholine receptor M2 |
11.424,00 €
Arecoline (hydrobromide)
Artikelnummer: Cay13662-250
Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively. Generally, arecoline causes smooth muscle contraction. Arecoline and other muscarinic...
| Schlagworte: | 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, monohydrobromide |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 300-08-3 |
| MW: | 236.1 D |
ab 29,00 €
Atropine
Artikelnummer: Cay12008-1
Atropine is a naturally occurring tropane alkaloid extracted from plants of the family Solanaceae including deadly nightshade (A. belladonna). It is a non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8). Atropine increases firing of...
| Schlagworte: | DL-Hyoscyamine, Tropine tropate, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester-benzeneacetic acid |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 51-55-8 |
| MW: | 289.4 D |
ab 38,00 €
(+)-Pilocarpine (hydrochloride)
Artikelnummer: Cay14487-500
(+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (apparent Kis = 6, 8.2, and 6.9 µM, respectively). It induces salivary secretion in rats when...
| Schlagworte: | NSC 5746, (3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 54-71-7 |
| MW: | 244.7 D |
ab 56,00 €
LY2119620
Artikelnummer: Cay26373-5
LY2119620 is a positive allosteric modulator of the M2 and M4 muscarinic acetylcholine receptors (mAChRs). It binds to allosteric sites on M2 and M4 receptors with KB values ranging from 1.8 to 3.4 µM. LY2119620 potentiates the activity of the AChR agonist acetylcholine (ACh, Cay-23829) and the mAChR agonists...
| Schlagworte: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methyl-1-piperazinyl)-2-oxoethoxy]-thieno[2,3-b]pyridine-2-carboxamide |
| Anwendung: | Muscarinic acetylcholine receptor M2 / M4 positive allosteric modulator (PAM) |
| CAS | 886047-22-9 |
| MW: | 437.9 D |
ab 110,00 €
Oxotremorine M (iodide)
Artikelnummer: Cay20847-50
Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 µM, respectively). It also increases M4-induced inhibition of calcium currents in...
| Schlagworte: | N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium, monoiodide |
| Anwendung: | Muscarinic receptor agonist |
| CAS | 3854-04-4 |
| MW: | 322.2 D |
ab 108,00 €
Bethanechol (chloride)
Artikelnummer: Cay23830-1
Bethanechol is an agonist of muscarinic acetylcholine receptors with IC50 values of 1,837, 25, 631, 317, and 393 µM for M1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors. It inhibits M2-mediated increases in cyclic AMP induced by isoproterenol (Cay-15592) in isolated...
| Schlagworte: | (±)-Bethanechol, Carbamyl-beta-methylcholine chloride, NSC 30783, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium,... |
| Anwendung: | Muscarinic acetylcholine receptor agonist |
| CAS | 590-63-6 |
| MW: | 196.7 D |
ab 56,00 €
Oxybutynin (hydrochloride)
Artikelnummer: Cay23825-1
Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40 nM for human recombinant M1-5, respectively). It inhibits intracellular calcium mobilization induced by carbamoylcholine (carbachol, Cay-14486) in bladder smooth muscle and submandibular gland cells isolated from...
| Schlagworte: | MJ4309-1, 4-(diethylamino)-2-butyn-1-yl ester alpha-cyclohexyl-alpha-hydroxy-benzeneacetic acid, monohydrochloride |
| Anwendung: | Muscarinic cholinergic receptor antagonist |
| CAS | 1508-65-2 |
| MW: | 394 D |
ab 110,00 €
Dicyclomine (hydrochloride)
Artikelnummer: Cay23867-500
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol, Cay-14486) in guinea pig cortex (Ki = 12 nM, pA2 = 7.88). Dicyclomine (10 mg/kg,...
| Schlagworte: | Dicycloverine, [1,1'-bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride |
| Anwendung: | Muscarinic acetylcholine receptor M1 / M2 antagonist |
| CAS | 67-92-5 |
| MW: | 346 D |
ab 30,00 €
Umeclidinium (bromide)
Artikelnummer: Cay20700-10
Umeclidinium is an antagonist of muscarinic acetylcholine receptors (Kis = 0.05-0.16 nM for M1-M5 human recombinant receptors). It inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM) and bronchoconstriction in mice when administered intranasally (ED50 =...
| Schlagworte: | GSK573719, 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octane, monobromide |
| Anwendung: | Muscarinic acetylcholine receptor antagonist |
| CAS | 869113-09-7 |
| MW: | 508.5 D |
ab 181,00 €