Oxotremorine M (iodide)

Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 µM, respectively). It also increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 µM). Oxotremorine M inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 µM). It also directly inhibits KCNQ2/3 potassium channels, decreasing KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner.Formal Name: N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium, monoiodide. CAS Number: 3854-04-4. Molecular Formula: C11H19N2O . I. Formula Weight: 322.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Water: 100mM. SMILES: O=C1CCCN1CC#CC[N+](C)(C)C.[I-]. InChi Code: InChI=1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14,/h6-10H2,1-3H3,1H/q+1,/p-1. InChi Key: VVLMSCJCXMBGDI-UHFFFAOYSA-M.