Oxcarbazepine

Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ, Cay-18682) or picrotoxin (Cay-20771) in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.Formal Name: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide. CAS Number: 28721-07-5. Synonyms: GP47680. Molecular Formula: C15H12N2O2. Formula Weight: 252.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 256, 308 nm. SMILES: O=C1C2=C(C=CC=C2)N(C(N)=O)C3=C(C=CC=C3)C1. InChi Code: InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19). InChi Key: CTRLABGOLIVAIY-UHFFFAOYSA-N.