Zu "K04833" wurden 104 Artikel gefunden!
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Saxitoxin
Artikelnummer: Cay45566-500
Saxitoxin is a marine guanidinium toxin and voltage-gated sodium channel blocker (IC50 = 4.3 nM). It selectively binds to sodium channels in rat brain and skeletal muscle over rat heart homogenates (Kds = 0.114, 0.49, and 10 nM, respectively). Saxitoxin (3 and 10 µM) also inhibits L-type calcium channels in isolated...
| Schlagworte: | STX, (3aS,4R,10aS)-2,6-diamino-4-[[(aminocarbonyl)oxy]methyl]-3a,4,8,9-tetrahydro-1H,10H-pyrrolo[1,2-c]purine-10,10-diol |
| Anwendung: | Marine guanidinium toxin, voltage-gated sodium channel blocker |
| CAS | 35523-89-8 |
| MW: | 299.29 D |
452,00 €
Levobupivacaine hydrochloride
Artikelnummer: TGM-T6566-100mg
Description: Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor and the pure S(-)-enantiomer of bupivacaine, used as a long-acting local anesthetic. Target: Sodium Channel. Smiles: Cl.CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C. References: Foster RH, et...
| Schlagworte: | Levobupivacaine HCl, (S)-(-)-Bupivacaine HCl, (S)-(-)-Bupivacaine monohydrochloride |
| Anwendung: | Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1) |
| CAS | 27262-48-2 |
| MW: | 324.89 D |
ab 29,00 €
Grayanotoxin I
Artikelnummer: Cay42644-100
Grayanotoxin I is a diterpene toxin that has been found in R. ponticum nectar, a component of mad honey. It increases resting sodium permeability in squid axonal membranes when used at a concentration of 10 µM. Grayanotoxin I (0.25, 0.5, and 1 mg/kg) induces proteinuria and reduces serum levels of alanine...
| Schlagworte: | Acetylandromedol, Andromedotoxin, Asebotoxin, GTX I, NSC 26711, Rhodotoxin, grayanotoxane-3beta,5,6beta,10,14R,16-hexol,... |
| Anwendung: | Diterpene toxin, reversible Nav1.x agonist |
| CAS | 4720-09-6 |
| MW: | 412.52 D |
ab 193,00 €
Quinidine-d3
Artikelnummer: Cay28884-2.5
Quinidine-d3 is intended for use as an internal standard for the quantification of quinidine (Cay-20356) by GC- or LC-MS. Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent...
| Schlagworte: | (+)-Quinidine-d3, beta-Quinidine-d3, 6'-(methoxy-d3)-cinchonan-9S-ol |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, sodium channel blocker |
| CAS | 1267657-68-0 |
| MW: | 327.4 D |
514,00 €
Oxcarbazepine
Artikelnummer: Cay17340-10
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...
| Schlagworte: | GP47680, 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | 10-hydroxycarbazepine prodrug, voltage-gated sodium channel blocker |
| CAS | 28721-07-5 |
| MW: | 252.3 D |
ab 51,00 €
Zonisamide
Artikelnummer: Cay24183-100
Zonisamide is a broad-spectrum sulfonamide antiepileptic agent. It selectively blocks the repeated firing of sodium channels (IC50 = 2 µg/ml) at low concentrations in mouse embryo spinal cord neurons, and it blocks spontaneous channel firing at concentrations above 10 µg/ml. In rat cerebral cortex neurons,...
| Schlagworte: | CI-912, PD 110843, 1,2-benzisoxazole-3-methanesulfonamide |
| Anwendung: | Antiepileptic |
| CAS | 68291-97-4 |
| MW: | 212.2 D |
ab 89,00 €
Carbamazepine-d10
Artikelnummer: Cay33486-1
Carbamazepine-d10 is intended for use as an internal standard for the quantification of carbamazepine by GC- or LC-MS. Carbamazepine is an anticonvulsant. It reduces the occurrence of seizures in mouse models of tonic-clonic, or maximal electroshock-induced, seizures (ED50s = 15.46 and ~13 mg/kg, respectively)....
| Schlagworte: | Carbazepine-d10, 5H-dibenz[b,f]azepine-1,2,3,4,6,7,8,9,10,11-d10-5-carboxamide |
| Anwendung: | Internal standard, GC-MS, LC-MS, quantification, anticonvulsant |
| CAS | 132183-78-9 |
| MW: | 246.3 D |
ab 169,00 €
Mexiletine (hydrochloride)
Artikelnummer: Cay23782-10
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...
| Schlagworte: | Ko 1173, 1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride |
| Anwendung: | Sodium channel blocker |
| CAS | 5370-01-4 |
| MW: | 215.7 D |
ab 51,00 €
10,11-dihydro-10-hydroxy Carbamazepine
Artikelnummer: Cay18467-10
10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...
| Schlagworte: | 10,11-hydroxy-10,11 Dihydrocarbamezer, BIA 2-005, GP 47779, Licarbazepine,... |
| Anwendung: | Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker |
| CAS | 29331-92-8 |
| MW: | 254.3 D |
ab 78,00 €
Rufinamide
Artikelnummer: Cay18870-10
Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...
| Schlagworte: | CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
| Anwendung: | Antiepileptic |
| CAS | 106308-44-5 |
| MW: | 238.2 D |
ab 51,00 €
Fosphenytoin (sodium salt)
Artikelnummer: Cay23889-100
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker, in vivo. It induces less tissue damage compared with two other phenytoin prodrugs in rats following subcutaneous and intramuscular administration. Fosphenytoin has anticonvulsant activity in a mouse...
| Schlagworte: | ACC-9653, Cl-982, 5,5-diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione, disodium salt |
| Anwendung: | Voltage-gated sodium channel blocker prodrug |
| CAS | 92134-98-0 |
| MW: | 406.2 D |
ab 69,00 €
Eslicarbazepine
Artikelnummer: Cay35008-10
Eslicarbazepine is a voltage-gated sodium channel (Nav) inhibitor and an active metabolite of the prodrug eslicarbazepine acetate (Cay-23656). It enhances slow activation of voltage-gated sodium channels, reducing channel availability. Eslicarbazepine is protective against seizures induced by maximal electroshock...
| Schlagworte: | (S)-Licarbazepine, BIA 2-194, CGP 13751, (10S)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | Eslicarbazepine acetate active metabolite, voltage-gated sodium channel inhibitor |
| CAS | 104746-04-5 |
| MW: | 254.3 D |
ab 57,00 €