NHI 2

NHI 2 is an inhibitor of lactate dehydrogenase A (LDHA, IC50 = 14.7 µM). It is selective for LDHA over LDHB (IC50 = 55.8 µM). It inhibits lactate production in HeLa cells when used at concentrations of 100 and 200 µM. NHI 2 is cytotoxic to HeLa cells (IC50 = 33.4 µM).Formal Name: 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylic acid, methyl ester. CAS Number: 1269802-97-2. Molecular Formula: C17H12F3NO3. Formula Weight: 335.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. lambdamax: 256, 322 nm. SMILES: ON1C(C(OC)=O)=CC(C1=C2)=C(C(F)(F)F)C=C2C3=CC=CC=C3. InChi Code: InChI=1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3. InChi Key: YPPFWRWCZNXINO-UHFFFAOYSA-N.