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LDH Cytotoxicity Assay Kit Artikelnummer: Cay601170-480
Necrosis is accompanied by mitochondrial swelling and increased plasma membrane permeability, while apoptosis involves an articulated breakdown of the cell into membrane-bound apoptotic bodies. Lactate dehydrogenase (LDH) is a soluble cytosolic enzyme that is released into the culture medium following loss of...
| Schlagworte: | Lactate Dehydrogenase Cytotoxicity Assay Kite, raplacement of Cay10008882 |
| Anwendung: | Cell based assays |
| Reaktivität: | Broad |
ab 83,00 €
Sodium Oxamate Artikelnummer: Cay19057-5
Sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis. Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various...
| Schlagworte: | Oxalic Acid monoamide, Oxamic Acid, 2-amino-2-oxo-acetic acid, monosodium salt |
| Anwendung: | Glycolysis disruptor, Lactate dehydrogenase inhibitor |
| CAS | 565-73-1 |
| MW: | 111 D |
ab 58,00 €
GSK2837808A Artikelnummer: Cay20626-1
GSK2837808A is a potent inhibitor of lactate dehydrogenase (LDH) A and B (IC50s = 2.6 and 0.43 nM, for human recombinant LDHA and LDHB, respectively). It inhibits lactate production in Snu398 hepatocellular carcinoma cells in which LDHB expression is undetectable (EC50 = 400 nM). GSK2837808A (10 µM) reduces glucose...
| Schlagworte: | 3-[[3-[(cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)-benzoic acid |
| Anwendung: | LDHA inhibitor |
| CAS | 1445879-21-9 |
| MW: | 649.6 D |
ab 44,00 €
Amplite(TM) Colorimetric L-Lactate Dehydrogenase (LDH)... Artikelnummer: ABD-13813
Ex: 575 nm. Lactate dehydrogenase (LDH) is an oxidoreductase enzyme that catalyzes the interconversion of pyruvate and lactate. LDH is present in cytosol of a wide variety of organisms, including animals and plants. Cells release LDH into the bloodstream after tissue damage or red blood cell hemolysis. Since LDH is...
| Anwendung: | Cell metabolism assay |
346,00 €
NHI 2 Artikelnummer: Cay30201-1
NHI 2 is an inhibitor of lactate dehydrogenase A (LDHA, IC50 = 14.7 µM). It is selective for LDHA over LDHB (IC50 = 55.8 µM). It inhibits lactate production in HeLa cells when used at concentrations of 100 and 200 µM. NHI 2 is cytotoxic to HeLa cells (IC50 = 33.4 µM).
| Schlagworte: | 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylic acid, methyl ester |
| Anwendung: | Lactate dehydrogenase A (LDHA) inhibitor |
| CAS | 1269802-97-2 |
| MW: | 335.3 D |
ab 32,00 €
Galloflavin Artikelnummer: Cay14846-5
Galloflavin is an inhibitor of both the A and B isoforms of lactate dehydrogenase (Kis = 5.46 and 15.06 µM, respectively). It has been shown to prevent proliferation of many different cancer cell lines in vitro by blocking glycolysis and ATP production.
| Schlagworte: | NSC 107022, 3,8,9,10-tetrahydroxy-pyrano[3,2-c][2]benzopyran-2,6-dione |
| Anwendung: | LDH inhibitor |
| CAS | 568-80-9 |
| MW: | 278.2 D |
ab 32,00 €
AZ 33 Artikelnummer: Cay25444-1
AZ 33 is an inhibitor of lactate dehydrogenase A (LDHA, Kd = 0.093 µM, IC50 = 0.5 µM). It is selective for LDHA over LDHB in an NADH competition assay using recombinant enzymes (IC50s = 0.54 and 3.6 µM, respectively). AZ 33 is cell-impermeable and lacks cytotoxicity against HeLa cervical cancer cells (IC50 = >500 µM).
| Schlagworte: | 2-[[4-[4-[[3-[(2-methyl-6-benzothiazolyl)amino]-3-oxopropyl]amino]-4-oxobutyl]phenyl]methyl]-propanedioic acid |
| Anwendung: | LDHA inhibitor |
| CAS | 1370290-34-8 |
| MW: | 497.6 D |
ab 32,00 €
LDHA, Human Recombinant Protein Artikelnummer: BPS-71081
Human Lactate dehydrogenase A (LDHA), GenBank Accession No. NM_005566), full length [2-332(end)] with N-terminal His-tag, MW= 37.5kDa, expressed in an E.coli expression system.
| Schlagworte: | LDHA, PIG19, LDH-M, LDH-A, EC=1.1.1.27, LDH muscle subunit, L-lactate dehydrogenase A chain, Renal carcinoma antigen... |
| Anwendung: | Enzyme kinetics, Screening inhibitors, Selectivity profiling |
| Reaktivität: | Human |
| MW: | 37.5 kD |
468,00 €
GSK2837808A Artikelnummer: AG-CR1-3685-M005
| Schlagworte: | 3-((3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid |
| Anwendung: | Potent, selective cell-permeable LDHA inhibitor |
| CAS | 1445879-21-9 |
| MW: | 649.6 D |
ab 44,00 €
LDHB, human recombinant protein, N-terminal His-tag Artikelnummer: BPS-71078
Human lactate dehydrogenase B (LDHB) amino-acids 2 - 334 (end) (GenBank Accession No. NM_002300) with N-terminal His tag, MW = 37.5 kDa, expressed in an E. coli expression system.
| Schlagworte: | LDHB, LDH-H, LDH-B, EC=1.1.1.27, LDH heart subunit, L-lactate dehydrogenase B chain, Renal carcinoma antigen NY-REN-46 |
| Anwendung: | Enzyme kinetics, inhibitor screening, Selectivity profiling |
| Reaktivität: | Human |
| MW: | 37.5 kD |
468,00 €
Human LDHA (Lactate Dehydrogenase A) CLIA Kit Artikelnummer: G-HUES00382.96
ELISA Type: CLIA. Sensitivity: 0.094 ng/mL. Range: 0.156--10 ng/mL. 0
| Schlagworte: | LDHA, PIG19, LDH-M, LDH-A, EC=1.1.1.27, LDH muscle subunit, L-lactate dehydrogenase A chain, Renal carcinoma antigen... |
| Anwendung: | CLIA |
| Reaktivität: | Human |
629,00 €