Midodrine (hydrochloride)

Midodrine is a prodrug form of the alpha1-adrenergic receptor (alpha1-AR) agonist desglymidodrine (Cay-35608). It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats. Formulations containing midodrine have been used in the treatment of orthostatic hypotension.Formal Name: 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-acetamide, monohydrochloride. CAS Number: 43218-56-0. Molecular Formula: C12H18N2O4 . HCl. Formula Weight: 290.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 290 nm. SMILES: OC(CNC(CN)=O)C1=C(OC)C=CC(OC)=C1.Cl. InChi Code: InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13,/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16),1H. InChi Key: MGCQZNBCJBRZDT-UHFFFAOYSA-N.