Zu "K04135" wurden 113 Artikel gefunden!
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WB 4101 (hydrochloride)
Artikelnummer: Cay29528-25
WB 4101 is an antagonist of alpha-adrenergic receptors (alpha-ARs). It inhibits norepinephrine-induced contraction of isolated rat vas deferens (pA2 = 9.8). WB 4101 also inhibits contractions induced by carbachol (carbamoylcholine, Cay-14486) in isolated guinea pig taenia caeci (pA2 = 8.9). Formal Name:...
| Schlagworte: | N-[2-(2,6-dimethoxyphenoxy)ethyl]-2,3-dihydro-1,4-benzodioxin-2-methanamine, monohydrochloride |
| Anwendung: | alpha-adrenergic receptor antagonist |
| CAS | 2170-58-3 |
| MW: | 381.85 D |
304,00 €
CHO-K1/ADRA1A Stable Cell Line
Artikelnummer: GSC-M00225
Recombinant CHO-K1 cells stably overexpress human adrenoceptor alpha 1A (ADRA1A) on the surface and contain high levels of G protein Galphaq to couple with the receptor in downstream signaling pathways.
| Schlagworte: | ADRA1A, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1A adrenergic receptor, Alpha-adrenergic receptor 1c |
11.424,00 €
Urapidil-d3
Artikelnummer: Cay43811-1
Urapidil-d3 is intended for use as an internal standard for the quantification of urapidil (Cay29004) by GC- or LC-MS. Urapidil is an antagonist of alpha1-adrenergic receptors (alpha1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to alpha1- over alpha2-ARs (IC50s =...
| Schlagworte: | 6-((3-(4-(2-(methoxy-d3)phenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione |
| Anwendung: | GC-MS, LC-MS, internal standard, quantification, alpha1-adrenergic receptor antagonist |
| CAS | 1398066-08-4 |
| MW: | 390.5 D |
ab 207,00 €
Adrenalone (hydrochloride)
Artikelnummer: Cay43563-1
An oxidized derivative of epinephrine, induces dsDNA breaks in RFL-6 fibroblasts at 250 µM, increases the blood levels of fibrinogen in rats at 20 mg/kg
| Schlagworte: | 1-(3,4-dihydroxyphenyl)-2-(methylamino)-ethanone, monohydrochloride |
| Anwendung: | Oxidized epinephrine derivative, adrenergic receptor agonist |
| CAS | 62-13-5 |
| MW: | 217.7 D |
ab 73,00 €
BMY 14802 (hydrochloride)
Artikelnummer: Cay42264-10
An atypical antipsychotic, selectively binds to sigma receptors over alpha1-ARs and dopamine D2 receptors (IC50s = 112, 520, and 6,340 nM, respectively), inhibits the conditioned avoidance response and apomorphine-induced stereotypy in rats (ED50s = 26.4 and 33 mg/kg, respectively). Formulation: A solid. InChI:...
| Schlagworte: | BMS 181100, a-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol, monohydrochloride |
| Anwendung: | Atypical antipsychotic |
| CAS | 105565-55-7 |
| MW: | 384.85 D |
ab 88,00 €
Carvedilol
Artikelnummer: Cay15418-50
Carvedilol is an antagonist of the beta-adrenergic receptor (beta-AR, Kds = 1.78, 0.4, and 5.01 nM for beta1-, beta2-, and beta3-ARs, respectively). It also selectively binds to alpha1- over alpha2-ARs (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the beta1-AR...
| Schlagworte: | BM 14190, 1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
| Anwendung: | alpha1 / beta adrenergic receptor antagonist |
| CAS | 72956-09-3 |
| MW: | 406.5 D |
ab 49,00 €
Prazosin (hydrochloride)
Artikelnummer: Cay15023-50
Prazosin is an antagonist of alpha1-adrenergic receptors (alpha1-ARs). It selectively binds to alpha1-ARs with Ki values of 0.2, 0.25, and 0.32 nM for the human recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, over alpha2-ARs (Kis = 340 and 3.7 nM in alpha2A-AR-expressing HT-29 cells and...
| Schlagworte: | CP 12,299-1, NSC 292810, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-furanyl-methanone, monohydrochloride |
| Anwendung: | Antihypertensive agent, melatonin MT3 receptor antagonist |
| CAS | 19237-84-4 |
| MW: | 419.9 D |
ab 49,00 €
COVID-19 Forschung
Ifenprodil (hemitartrate)
Artikelnummer: Cay17201-50
Ifenprodil is an antagonist of NR1A/NR2B subunit-containing NMDA receptors (IC50 = 340 nM). It is selective for NR1A/NR2B subunit-containing NMDA receptors over those containing NR1A/NR2A or NR1A/NR2C subunits (IC50s = 20 and >100 µM, respectively) but also binds to sigma 1 (sigma1) receptors, emopamil binding...
| Schlagworte: | NP-120, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethanol, 2R,3R-dihydroxybutanedioate (2:1) |
| Anwendung: | N-methyl-D-aspartate receptor (NMDA) NR2B-selective antagonist, alpha1-adrenergic receptor antagonist |
| CAS | 23210-58-4 |
| MW: | 400.5 D |
ab 49,00 €
L-Phenylephrine
Artikelnummer: Cay17205-500
L-Phenylephrine is an adrenergic alpha1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the alpha1B and alpha1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively). By stimulating adrenergic alpha1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported...
| Schlagworte: | (R)-(-)-Phenylephrine, 3-hydroxy-alphaR-[(methylamino)methyl]-benzenemethanol |
| Anwendung: | Adrenoceptor alpha 1A agonist |
| CAS | 59-42-7 |
| MW: | 167.2 D |
ab 49,00 €
Tolazoline (hydrochloride)
Artikelnummer: Cay18865-5
Tolazoline is an alpha1-adrenergic receptor (alpha1-AR, IC50 = 3,200 nM) and alpha2-AR antagonist (Kis = 112, 1,230, 354, and 173 nM for alpha2A, alpha2B-, alpha2C-, and alpha2D-ARs, respectively). Tolazoline inhibits alpha-AR agonist-induced contractions in isolated human corpus cavernosum smooth muscle (IC50 = 0.1...
| Schlagworte: | 4,5-dihydro-2-(phenylmethyl)-1H-imidazole, monohydrochloride |
| Anwendung: | alpha1/2-adrenergic receptor antagonist |
| CAS | 59-97-2 |
| MW: | 196.7 D |
ab 49,00 €
Cirazoline (hydrochloride)
Artikelnummer: Cay21791-5
Cirazoline is an alpha1-adrenergic receptor (alpha1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant alpha1A-, alpha1B-, and alpha1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at alpha1A- and a partial agonist at alpha1B- and alpha1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM,...
| Schlagworte: | 2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole, monohydrochloride |
| Anwendung: | alpha-1A adrenoreceptor agonist |
| CAS | 40600-13-3 |
| MW: | 252.7 D |
ab 127,00 €
Alfuzosin (hydrochloride)
Artikelnummer: Cay13648-10
Alfuzosin is a post-synaptic alpha1-adrenergic receptor antagonist commonly used to improve lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). It displays high-affinity with non-selectivity for the three known human alpha1 adrenoceptors (pKi = 8.0, 8.0, and 8.5 for alpha1A, alpha1B, and...
| Schlagworte: | SL 77499-10, Uroxatral, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide,... |
| Anwendung: | alpha1-adrenergic receptor antagonist |
| CAS | 81403-68-1 |
| MW: | 425.9 D |
ab 67,00 €