Mexiletine (hydrochloride)

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 µg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.Formal Name: 1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride. CAS Number: 5370-01-4. Synonyms: Ko 1173. Molecular Formula: C11H17NO . HCl. Formula Weight: 215.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMSO: 10 mg/mL, Ethanol: 30 mg/mL, PBS (pH 7.2): 10 mg/mL. SMILES: CC1=CC=CC(C)=C1OCC(C)N.Cl. InChi Code: InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12,/h4-6,10H,7,12H2,1-3H3,1H. InChi Key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N.