Zu "K04834" wurden 43 Artikel gefunden!

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Eslicarbazepine
Eslicarbazepine

Artikelnummer: Cay35008-1

Eslicarbazepine is a voltage-gated sodium channel (Nav) inhibitor and an active metabolite of the prodrug eslicarbazepine acetate (Cay-23656). It enhances slow activation of voltage-gated sodium channels, reducing channel availability. Eslicarbazepine is protective against seizures induced by maximal electroshock...
Schlagworte: (S)-Licarbazepine, BIA 2-194, CGP 13751, (10S)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
Anwendung: Eslicarbazepine acetate active metabolite, voltage-gated sodium channel inhibitor
CAS 104746-04-5
MW: 254.3 D
ab 48,00 €
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Fenvalerate
Fenvalerate

Artikelnummer: Cay29399-100

Fenvalerate is a pyrethroid ester insecticide and acaricide. It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8). It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly). Fenvalerate also induces mortality in tobacco budworm larvae but is...
Schlagworte: 4-chloro-alpha-(1-methylethyl)-benzeneacetic acid, cyano(3-phenoxyphenyl)methyl ester
Anwendung: Antiparasitic, insecticide, Nav1.8 slow activator
CAS 51630-58-1
MW: 419.9 D
ab 44,00 €
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Mepivacaine
Mepivacaine

Artikelnummer: Cay23402-5

Mepivacaine (Cay-23402) is an analytical reference standard that is categorized as an anesthetic. This product is intended for research and forensic applications.Formal Name: N-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide. CAS Number: 96-88-8. Molecular Formula: C15H22N2O. Formula Weight: 246.4. Purity:...
Schlagworte: N-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide
Anwendung: Analytical reference standard, Anesthetic
CAS 96-88-8
MW: 246.4 D
ab 42,00 €
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Tetracaine
Tetracaine

Artikelnummer: Cay30059-5

Tetracaine (Cay-30059) is an analytical reference standard categorized as an anesthetic. Tetracaine has been found as an adulterant in products marketed as male sexual function enhancers. This product is intended for research and forensic applications.Formal Name: 4-(butylamino)-benzoic acid, 2-(dimethylamino)ethyl...
Schlagworte: Tetracain, 4-(butylamino)-benzoic acid, 2-(dimethylamino)ethyl ester
Anwendung: Analytical reference standard, Local anesthetic, Adulterant
CAS 94-24-6
MW: 264.4 D
ab 39,00 €
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Propafenone (hydrochloride)
Propafenone (hydrochloride)

Artikelnummer: Cay21871-1

Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium...
Schlagworte: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride
Anwendung: Sodium channel blocker
CAS 34183-22-7
MW: 377.9 D
ab 43,00 €
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Lamotrigine
Lamotrigine

Artikelnummer: Cay15428-10

Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
Schlagworte: BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Anwendung: Voltage-gated sodium channel inhibitor
CAS 84057-84-1
MW: 256.1 D
ab 77,00 €
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Brevetoxin B
Brevetoxin B

Artikelnummer: Cay10011498-100

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal,...
Schlagworte: Brevetoxin 2, BTX-B, GbTx-2, PbTx-2, brevetoxin B
Anwendung: Polyketide neurotoxin
CAS 79580-28-2
MW: 895.1 D
369,00 €
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Mexiletine (hydrochloride)
Mexiletine (hydrochloride)

Artikelnummer: Cay23782-5

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...
Schlagworte: Ko 1173, 1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride
Anwendung: Sodium channel blocker
CAS 5370-01-4
MW: 215.7 D
ab 43,00 €
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Anti-Nav1.2, clone S69-3
Anti-Nav1.2, clone S69-3

Artikelnummer: 200-301-G19

Anti-Nav1.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.2 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Nav1.2 from other sources has not been determined. Ion Channels research. Protein...
Schlagworte: Anti-Scn2a, Anti-Scn2a1, Anti-Sodium channel protein type 2 subunit alpha, Anti-Sodium channel protein type II subunit...
Anwendung: IHC, IFM, IP, WB
Wirt: Mouse
Spezies-Reaktivität: human, mouse, rat
698,00 €
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(-)-Ropivacaine-d7 (hydrochloride)
(-)-Ropivacaine-d7 (hydrochloride)

Artikelnummer: Cay26495-500

(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...
Schlagworte: (S)-Ropivacaine-d7, (S)-N-(2,6-dimethylphenyl)-1-(propyl-d7)piperidine-2-carboxamide, monohydrochloride
Anwendung: GC-MS, LC-MS, Quantification, Internal standard, Sodium channel blocker
CAS 1217667-10-1
MW: 317.9 D
ab 139,00 €
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Lamotrigine-d3
Lamotrigine-d3

Artikelnummer: Cay37196-1

Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Cay-15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM,...
Schlagworte: LTG-d3, 6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine
Anwendung: GC-MS, LC-MS internal standard, quantification, oltage-gated sodium channel inhibitor
CAS 1132746-94-1
MW: 259.1 D
ab 225,00 €
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10,11-dihydro-10-hydroxy Carbamazepine
10,11-dihydro-10-hydroxy Carbamazepine

Artikelnummer: Cay18467-25

10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...
Schlagworte: 10,11-hydroxy-10,11 Dihydrocarbamezer, BIA 2-005, GP 47779, Licarbazepine,...
Anwendung: Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker
CAS 29331-92-8
MW: 254.3 D
ab 68,00 €
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