Zu "K04834" wurden 59 Artikel gefunden!
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Propafenone (hydrochloride)
Artikelnummer: Cay44945-25
Propafenone (hydrochloride) (Cay-44945) is an analytical reference standard categorized as a class IC antiarrhythmic agent. Propafenone has been associated with accidental and intentional overdose. Formulations containing propafenone have been used in the treatment of cardiac arrhythmias. This product is intended...
| Schlagworte: | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride |
| Anwendung: | Analytical reference standard, class IC antiarrhythmic agent |
| CAS | 34183-22-7 |
| MW: | 377.91 D |
ab 95,00 €
Mexiletine (hydrochloride)
Artikelnummer: Cay23782-5
Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED50 values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or...
| Schlagworte: | Ko 1173, 1-(2,6-dimethylphenoxy)-2-propanamine, monohydrochloride |
| Anwendung: | Sodium channel blocker |
| CAS | 5370-01-4 |
| MW: | 215.7 D |
ab 49,00 €
Propafenone (hydrochloride)
Artikelnummer: Cay21871-1
Propafenone is a class I antiarrhythmic agent. It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively). Propafenone also blocks sodium...
| Schlagworte: | 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, monohydrochloride |
| Anwendung: | Sodium channel blocker |
| CAS | 34183-22-7 |
| MW: | 377.9 D |
ab 49,00 €
Lamotrigine
Artikelnummer: Cay15428-10
Lamotrigine is an anticonvulsant. It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 µM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can...
| Schlagworte: | BW 430C, Epilepax, Lamictal, LTG, 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 84057-84-1 |
| MW: | 256.1 D |
ab 85,00 €
(-)-Ropivacaine-d7 (hydrochloride)
Artikelnummer: Cay26495-500
(-)-Ropivacaine-d7 is intended for use as an internal standard for the quantification of (-)-ropivacaine (Cay-21422) by GC- or LC-MS. (-)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (-)-ropivacaine induces complete impairment of proprioception, motor function, and...
| Schlagworte: | (S)-Ropivacaine-d7, (S)-N-(2,6-dimethylphenyl)-1-(propyl-d7)piperidine-2-carboxamide, monohydrochloride |
| Anwendung: | GC-MS, LC-MS, quantification, internal standard, sodium channel blocker |
| CAS | 1217667-10-1 |
| MW: | 317.9 D |
ab 163,00 €
Fenvalerate
Artikelnummer: Cay29399-100
Fenvalerate is a pyrethroid ester insecticide and acaricide. It is a slow activator of voltage-gated sodium channel 1.8 (Nav1.8). It induces mortality in pyrethroid-susceptible and -resistant strains of M. domestica (LD50s = 0.014-5 µg/fly). Fenvalerate also induces mortality in tobacco budworm larvae but is...
| Schlagworte: | 4-chloro-alpha-(1-methylethyl)-benzeneacetic acid, cyano(3-phenoxyphenyl)methyl ester |
| Anwendung: | Antiparasitic, insecticide, Nav1.8 slow activator |
| CAS | 51630-58-1 |
| MW: | 419.9 D |
ab 53,00 €
Eslicarbazepine
Artikelnummer: Cay35008-1
Eslicarbazepine is a voltage-gated sodium channel (Nav) inhibitor and an active metabolite of the prodrug eslicarbazepine acetate (Cay-23656). It enhances slow activation of voltage-gated sodium channels, reducing channel availability. Eslicarbazepine is protective against seizures induced by maximal electroshock...
| Schlagworte: | (S)-Licarbazepine, BIA 2-194, CGP 13751, (10S)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | Eslicarbazepine acetate active metabolite, voltage-gated sodium channel inhibitor |
| CAS | 104746-04-5 |
| MW: | 254.3 D |
ab 54,00 €
10,11-dihydro-10-hydroxy Carbamazepine
Artikelnummer: Cay18467-25
10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Cay-17340). It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES)...
| Schlagworte: | 10,11-hydroxy-10,11 Dihydrocarbamezer, BIA 2-005, GP 47779, Licarbazepine,... |
| Anwendung: | Anticonvulsant, voltage-gated sodium channel SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A blocker |
| CAS | 29331-92-8 |
| MW: | 254.3 D |
ab 75,00 €
Rufinamide
Artikelnummer: Cay18870-100
Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...
| Schlagworte: | CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
| Anwendung: | Antiepileptic |
| CAS | 106308-44-5 |
| MW: | 238.2 D |
ab 49,00 €
Raxatrigine (hydrochloride)
Artikelnummer: Cay23490-25
Raxatrigine is an inhibitor of voltage-gated sodium channels (Nav, IC50s = 22, 13, 23, 10, 84, 15, 32, and 6 µM for Nav1.1-Nav1.8 channels in a FLIPR membrane potential assay using HEK293 cells). Its activity is state-dependent at the Nav1.7 channel, with a nine-fold increase in potency for the open/inactivated...
| Schlagworte: | GSK1014802A, (2S)-5R-[4-[(2-fluorophenyl)methoxy]phenyl]-2-pyrrolidinecarboxamide, monohydrochloride |
| Anwendung: | Voltage-gated sodium channel inhibitor |
| CAS | 934240-31-0 |
| MW: | 350.8 D |
ab 56,00 €
Oxcarbazepine
Artikelnummer: Cay17340-100
Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine (Cay-18467). It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 µM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20...
| Schlagworte: | GP47680, 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide |
| Anwendung: | 10-hydroxycarbazepine prodrug, voltage-gated sodium channel blocker |
| CAS | 28721-07-5 |
| MW: | 252.3 D |
ab 49,00 €
Disopyramide
Artikelnummer: Cay23227-500
Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. It is a class Ia antiarrhythmic agent that delays conduction through the AV node and ventricles of the dog heart both in vivo (3 and 5 mg/kg) and in vitro...
| Schlagworte: | (±)-Disopyramide, Ritmilen, SC-7031, alpha-[2-[bis(1-methylethyl)amino]ethyl]-alpha-phenyl-2-pyridineacetamide |
| Anwendung: | Sodium channel blocker |
| CAS | 3737-09-5 |
| MW: | 339.5 D |
ab 60,00 €