Methysticin

Methysticin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline methochloride at the gamma-aminobutyric acid (GABA) receptor GABAA at 0.1 µM. Methysticin inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2D6.Formal Name: (6R)-6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one. CAS Number: 495-85-2. Synonyms: Kavatin, (+)-Methysticin, NSC 112158. Molecular Formula: C15H14O5. Formula Weight: 274.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/mL, DMSO: 5 mg/mL, DMSO:PBS (pH 7.2) (1:6): 0.1 mg/mL, Ethanol: 1 mg/mL. lambdamax: 208, 225, 265, 306 nm. SMILES: COC(C[C@H](/C=C/C1=CC=C(OCO2)C2=C1)O3)=CC3=O. InChi Code: InChI=1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+/t11-/m0/s1. InChi Key: GTEXBOVBADJOQH-FWEMWIAWSA-N.