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Zu "K17712" wurden 44 Artikel gefunden!
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Artikelnummer: Cay39547-10
Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist promethazine (Cay-16478). It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6.Formal Name: N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine, 5-oxide. CAS Number: 7640-51-9. Molecular Formula: C17H20N2OS. Formula...
Schlagworte: | N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine, 5-oxide |
Anwendung: | Promethazine metabolite |
CAS | 7640-51-9 |
MW: | 300.4 D |
ab 130,00 €
Artikelnummer: ELK-ELK5322.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CYP2D6. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CYP2D6....
Schlagworte: | CYPIID6, CYP2DL1, Cytochrome P450 2D6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, Cholesterol 25-hydroxylase |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: Cay20258-500
Methysticin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline methochloride at the gamma-aminobutyric acid (GABA) receptor GABAA at 0.1 µM. Methysticin inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2D6.Formal Name:...
Schlagworte: | Kavatin, NSC 112158, (6R)-6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one |
Anwendung: | CYP2C9 & CYP2D6 inhibitor |
CAS | 495-85-2 |
MW: | 274.3 D |
ab 43,00 €
Artikelnummer: Cay36659-1
cis-10-hydroxy Nortriptyline is an active metabolite of the tricyclic antidepressants amitriptyline (Cay-15881) and nortriptyline (Cay-15904). It is formed from amitriptyline and nortriptyline by the cytochrome P450 (CYP) isoform CYP2D6. cis-10-hydroxy Nortriptyline inhibits norepinephrine reuptake in rat cortical...
Schlagworte: | 10(Z)-hydroxy Nortriptyline, (5Z)-10,11-dihydro-5-[3-(methylamino)propylidene]-5H-dibenzo[a,d]cyclohepten-10-ol |
Anwendung: | Amitriptyline / nortriptyline active metabolite |
CAS | 47132-19-4 |
MW: | 279.4 D |
ab 58,00 €
Artikelnummer: Cay14854-10
(Z)-4-hydroxy Tamoxifen is an active metabolite of the estrogen receptor (ER) modulator tamoxifen (Cay-13258). It is primarily formed from tamoxifen by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP2B6. (Z)-4-hydroxy Tamoxifen (10 nM) decreases progesterone receptor (PR) mRNA expression induced by the estrogen...
Schlagworte: | trans-4-hydroxy Tamoxifen, ICI 79280, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
Anwendung: | Tamoxifen metabolite |
CAS | 68047-06-3 |
MW: | 387.5 D |
ab 50,00 €
Artikelnummer: Cay21502-5
(E/Z)-Endoxifen is an active metabolite of tamoxifen (Cay-13258) produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to...
Schlagworte: | (E/Z)-N-desmethyl-4-hydroxy Tamoxifen, 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
Anwendung: | Tamoxifen metabolite |
CAS | 110025-28-0 |
MW: | 373.5 D |
ab 61,00 €
Artikelnummer: Cay22160-500
1'-hydroxy Bufuralol is a metabolite of bufuralol (Cay-17794). Bufuralol is metabolized by the cytochrome P450 isoforms 2D1 and 2D2 (CYP2D1/2), therefore, quantification of the bufuralol metabolite, 1'-hydroxy bufuralol, can be used to determine CYP2D1/2 enzyme activity in humans and rats.Formal Name:...
Schlagworte: | Ro 03-7410, alpha2-[[(1,1-dimethylethyl)amino]methyl]-alpha7-methyl-2,7-benzofurandimethanol |
Anwendung: | Metabolite |
CAS | 57704-16-2 |
MW: | 277.4 D |
ab 254,00 €
Artikelnummer: Cay27833-1
5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine (Cay-15027) and fesoterodine (Cay-23777). It is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases. 5-hydroxymethyl Tolterodine inhibits M1-5...
Schlagworte: | 5-HMT, Desfesoterodine, PNU 200577, formic acid, compd. with... |
Anwendung: | Active metabolite |
CAS | 380636-49-7 |
MW: | 387.5 D |
406,00 €
Artikelnummer: G-HUFI00568.96
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
641,00 €
Artikelnummer: Cay19539-1
Dehydro Aripiprazole is a metabolite of the atypical antipsychotic aripiprazole (Cay-19989). It is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6.Formal Name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-2(1H)-quinolinone, monohydrochloride. CAS Number: 1008531-60-9. Molecular...
Schlagworte: | 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-2(1H)-quinolinone, monohydrochloride |
Anwendung: | Aripiprazole metabolite |
CAS | 1008531-60-9 |
MW: | 482.8 D |
ab 130,00 €
Artikelnummer: Cay22365-1
O-Desmethyl gefitinib is the major metabolite of gefitinib (Cay-13166) in human plasma, formed by the cytochrome P450 isoform CYP2D6. It is an active metabolite that inhibits EGFR similarly to gefitinib in subcellular assays (IC50s = 36 and 22 nM, respectively) but is less active in whole cell assays (IC50s = 760...
Schlagworte: | 4-[(3-chloro-4-fluorophenyl)amino]-6-[3-(4-morpholinyl)propoxy]-7-quinazolinol |
Anwendung: | Metabolite, EGFR inhibitor |
CAS | 847949-49-9 |
MW: | 432.9 D |
ab 37,00 €
Artikelnummer: E-AB-13178.120
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize...
Schlagworte: | Anti-CYP2D6, Anti-CYP2DL1, Anti-CYPIID6, Anti-Cytochrome P450-DB1, Anti-Cytochrome P450 2D6, Anti-Cholesterol... |
Anwendung: | IHC, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 71,00 €