LY2603618

LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents. It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation. LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of chemotherapeutic agents such as gemcitabine (Cay-11690).Formal Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)-urea. CAS Number: 911222-45-2. Synonyms: IC-83, Rabusertib. Molecular Formula: C18H22BrN5O3. Formula Weight: 436.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 212, 226, 254, 299 nm. SMILES: CC1=C(Br)C=C(NC(NC2=NC=C(C)N=C2)=O)C(OC[C@H]3OCCNC3)=C1. InChi Code: InChI=1S/C18H22BrN5O3/c1-11-5-16(27-10-13-8-20-3-4-26-13)15(6-14(11)19)23-18(25)24-17-9-21-12(2)7-22-17/h5-7,9,13,20H,3-4,8,10H2,1-2H3,(H2,22,23,24,25)/t13-/m0/s1. InChi Key: SYYBDNPGDKKJDU-ZDUSSCGKSA-N.