KRP 203

KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea and colonic inflammatory cell infiltration, and increases colon length in an IL10-/- mouse model of colitis. KRP 203 inhibits inflammatory cell infiltration and prolongs allograft survival in a rat model of minor histocompatibility complex-disparate heart transplantation.Formal Name: 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol, monohydrochloride. CAS Number: 509088-69-1. Synonyms: Mocravimod (hydrochloride). Molecular Formula: C24H26ClNO3S . HCl. Formula Weight: 480.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 15 mg/ml. SMILES: Cl.OCC(N)(CO)CCc1ccc(Sc2cccc(Oc3ccccc3)c2)cc1Cl. InChi Code: InChI=1S/C23H24ClNO3S.ClH/c24-22-14-21(10-9-17(22)11-12-23(25,15-26)16-27)29-20-8-4-7-19(13-20)28-18-5-2-1-3-6-18,/h1-10,13-14,26-27H,11-12,15-16,25H2,1H. InChi Key: HBJMPJWEMFBTMU-UHFFFAOYSA-N.