KIN1148

KIN1148 is an IFN regulating factor 3 (IRF3) activator and adjuvant. It increases the mRNA expression of the genes encoding IFN-stimulated gene 54 (ISG54) and 2'-5'-oligoadenylate synthase-like (OASL) protein in PH5CH8 cells and increases chemokine (C-X-C motif) ligand 10 (CXCL10) production in phorbol 12-myristate 13-acetate-differentiated THP-1 monocytes when used at a concentration of 10 µM. Immunization with a vaccine in combination with KIN1148 as an adjuvant increases blood IgG, neutralizing, and hemagglutinin antibody titers, decreases particle-forming units (PFUs) in the lungs and lung-draining lymph nodes, and increases the survival percentage of mice infected with a lethal dose of influenza virus.Formal Name: N-benzo[1,2-d:3,4-d']bisthiazol-2-yl-2-naphthalenecarboxamide. CAS Number: 1428729-56-9. Molecular Formula: C19H11N3OS2. Formula Weight: 361.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: Slightly soluble. lambdamax: 217, 249, 310, 326 nm. SMILES: O=C(C1=CC2=C(C=CC=C2)C=C1)NC3=NC4=C(S3)C5=C(SC=N5)C=C4. InChi Code: InChI=1S/C19H11N3OS2/c23-18(13-6-5-11-3-1-2-4-12(11)9-13)22-19-21-14-7-8-15-16(17(14)25-19)20-10-24-15/h1-10H,(H,21,22,23). InChi Key: YAISOECYKYATLL-UHFFFAOYSA-N.