JNJ-42153605

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2, EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50 = 5.4 mg/kg).Formal Name: 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine. CAS Number: 1254977-87-1. Molecular Formula: C22H23F3N4. Formula Weight: 400.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 260, 336 nm. SMILES: FC(C1=C(C=CN2C1=NN=C2CC3CC3)N(CC4)CCC4C5=CC=CC=C5)(F)F. InChi Code: InChI=1S/C22H23F3N4/c23-22(24,25)20-18(10-13-29-19(14-15-6-7-15)26-27-21(20)29)28-11-8-17(9-12-28)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2. InChi Key: BQAVZGJJQFJSMW-UHFFFAOYSA-N.