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LY379268
LY379268

Artikelnummer: Cay15351-10

LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over...
Schlagworte: (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Anwendung: mGluR2 / mGluR3 agonist
CAS 191471-52-0
MW: 187.2 D
ab 68,00 €
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Anti-mGluR2 / Metabotropic Glutamate Receptor 2 / GRM2
Anti-mGluR2 / Metabotropic Glutamate Receptor 2 / GRM2

Artikelnummer: NSJ-RQ5579

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic...
Schlagworte: Anti-mGluR2, Anti-GPRC1B, Anti-Metabotropic glutamate receptor 2, mGluR2 Antibody / Metabotropic Glutamate Receptor 2 / GRM2
Anwendung: WB, FC, IHC (paraffin), Direct ELISA
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
755,00 €
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Biphenylindanone A
Biphenylindanone A

Artikelnummer: Cay11986-25

The metabotropic glutamate receptor 2 (mGluR2) is a Gi/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA. Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC50...
Schlagworte: BINA, MRLSD 230, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic...
Anwendung: mGluR2 modulator
CAS 866823-73-6
MW: 454.6 D
ab 142,00 €
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LY341495
LY341495

Artikelnummer: Cay14693-10

LY341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4...
Schlagworte: alphaS-amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid
Anwendung: Group II mGluR antagonist
CAS 201943-63-7
MW: 353.4 D
ab 60,00 €
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LY404039
LY404039

Artikelnummer: Cay18408-25

LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms). It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by...
Schlagworte: (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Anwendung: mGluR-2 & mGluR-3 agonist
CAS 635318-11-5
MW: 235.2 D
ab 43,00 €
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Xanthurenic Acid
Xanthurenic Acid

Artikelnummer: Cay19191-500

Xanthurenic acid is formed upon tryptophan degradation by indoleamine 2,3-dioxygenase. It has been shown to be an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist and is implicated in the pathophysiology of schizophrenia. Xanthurenic acid has also been identified as an inducer of...
Schlagworte: NSC 401570, Xanthurenate, 4,8-dihydroxy-2-quinolinecarboxylic acid
Anwendung: Tryptophan degradation product, Endogenous mGluR2 / mGluR3 agonist
CAS 59-00-7
MW: 205.2 D
ab 43,00 €
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CPPG
CPPG

Artikelnummer: Cay34362-10

CPPG is an antagonist of group II and group III metabotropic glutamate receptors (mGluRs). It reverses inhibition of forskolin-induced cAMP accumulation induced by the mGluR group II selective agonist L-CCG-1 or the mGluR group III-selective agonist L-AP4 (Cay-14538) in rat cerebrocortical slices (IC50s = 46.2 and...
Schlagworte: alpha-Cyclopropyl-4-phosphonophenylglycine, alpha-amino-alpha-cyclopropyl-4-phosphono-benzeneacetic acid
Anwendung: Group II and group III mGluR antagonist
CAS 183364-82-1
MW: 271.2 D
ab 50,00 €
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Anti-GRM2
Anti-GRM2

Artikelnummer: NSJ-R34424-100UG

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Glutamate receptor, metabotropic 2 Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding...
Schlagworte: Anti-GPRC1B, Anti-mGluR2, Anti-Metabotropic glutamate receptor 2, GRM2 Antibody
Anwendung: WB, IHC, ELISA (peptide)
Wirt: Goat
Spezies-Reaktivität: human
755,00 €
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LY354740
LY354740

Artikelnummer: Cay24215-1

LY354740 is an agonist of the group II metabotropic glutamate receptor (mGluR) subtypes mGluR2 and mGluR3 (Kis = 99 and 94 nM, respectively). It inhibits forskolin-stimulated cAMP accumulation in cells expressing human mGluR2 and mGluR3 (EC50s = 5.1 and 24.3 nM, respectively) and is selective for mGluR2 and mGluR3...
Schlagworte: (1S,2S,5R,6S)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Anwendung: mGluR2 / mGluR3 agonist
CAS 176199-48-7
MW: 185.2 D
ab 44,00 €
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ACPT-II
ACPT-II

Artikelnummer: Cay78020-50

ACPT-II is a general competitive antagonist of metabotropic glutamate (mGlu) receptors. The KB values for mGlu1a, mGlu2, and mGlu4a receptors are 115, 88, and 77 µM, respectively. It binds to the large extracellular domain called a Venus flytrap module, where agonists bind. ACPT-II is a stereoisomer of the group III...
Schlagworte: 4-amino-1alpha,2alpha,4beta-cyclopentanetricarboxylic acid
Anwendung: Competitive metabotropic glutamate (mGlu) receptor antagonist
CAS 195209-04-2
MW: 217.2 D
ab 60,00 €
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CMPDA
CMPDA

Artikelnummer: Cay14626-1

CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2. It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 µM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well...
Schlagworte: N,N'-(1,4-phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide
Anwendung: GluR2 positive allosteric modulator
CAS 380607-77-2
MW: 376.5 D
ab 50,00 €
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JNJ-42153605
JNJ-42153605

Artikelnummer: Cay21984-1

JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2, EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50...
Schlagworte: 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine
Anwendung: Positive allosteric mGlu2 receptor modulator
CAS 1254977-87-1
MW: 400.4 D
ab 50,00 €
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