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Zu "K04605" wurden 31 Artikel gefunden!
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Artikelnummer: Cay15351-10
LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3. In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over...
Schlagworte: | (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
Anwendung: | mGluR2 / mGluR3 agonist |
CAS | 191471-52-0 |
MW: | 187.2 D |
ab 68,00 €
Artikelnummer: NSJ-RQ5579
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic...
Schlagworte: | Anti-mGluR2, Anti-GPRC1B, Anti-Metabotropic glutamate receptor 2, mGluR2 Antibody / Metabotropic Glutamate Receptor 2 / GRM2 |
Anwendung: | WB, FC, IHC (paraffin), Direct ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Artikelnummer: Cay11986-25
The metabotropic glutamate receptor 2 (mGluR2) is a Gi/o-coupled receptor which is expressed on presynaptic nerve terminals and modulates the release of neurotransmitters like glutamate and GABA. Biphenylindanone A (BINA) is a positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC50...
Schlagworte: | BINA, MRLSD 230, 3'-[[(2-cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic... |
Anwendung: | mGluR2 modulator |
CAS | 866823-73-6 |
MW: | 454.6 D |
ab 142,00 €
Artikelnummer: Cay14693-10
LY341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4...
Schlagworte: | alphaS-amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid |
Anwendung: | Group II mGluR antagonist |
CAS | 201943-63-7 |
MW: | 353.4 D |
ab 60,00 €
Artikelnummer: Cay18408-25
LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms). It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by...
Schlagworte: | (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide |
Anwendung: | mGluR-2 & mGluR-3 agonist |
CAS | 635318-11-5 |
MW: | 235.2 D |
ab 43,00 €
Artikelnummer: Cay19191-500
Xanthurenic acid is formed upon tryptophan degradation by indoleamine 2,3-dioxygenase. It has been shown to be an endogenous Group II metabotropic glutamate receptor (mGluR2 and mGluR3) agonist and is implicated in the pathophysiology of schizophrenia. Xanthurenic acid has also been identified as an inducer of...
Schlagworte: | NSC 401570, Xanthurenate, 4,8-dihydroxy-2-quinolinecarboxylic acid |
Anwendung: | Tryptophan degradation product, Endogenous mGluR2 / mGluR3 agonist |
CAS | 59-00-7 |
MW: | 205.2 D |
ab 43,00 €
Artikelnummer: Cay34362-10
CPPG is an antagonist of group II and group III metabotropic glutamate receptors (mGluRs). It reverses inhibition of forskolin-induced cAMP accumulation induced by the mGluR group II selective agonist L-CCG-1 or the mGluR group III-selective agonist L-AP4 (Cay-14538) in rat cerebrocortical slices (IC50s = 46.2 and...
Schlagworte: | alpha-Cyclopropyl-4-phosphonophenylglycine, alpha-amino-alpha-cyclopropyl-4-phosphono-benzeneacetic acid |
Anwendung: | Group II and group III mGluR antagonist |
CAS | 183364-82-1 |
MW: | 271.2 D |
ab 50,00 €
Artikelnummer: NSJ-R34424-100UG
0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Glutamate receptor, metabotropic 2 Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding...
Schlagworte: | Anti-GPRC1B, Anti-mGluR2, Anti-Metabotropic glutamate receptor 2, GRM2 Antibody |
Anwendung: | WB, IHC, ELISA (peptide) |
Wirt: | Goat |
Spezies-Reaktivität: | human |
755,00 €
Artikelnummer: Cay24215-1
LY354740 is an agonist of the group II metabotropic glutamate receptor (mGluR) subtypes mGluR2 and mGluR3 (Kis = 99 and 94 nM, respectively). It inhibits forskolin-stimulated cAMP accumulation in cells expressing human mGluR2 and mGluR3 (EC50s = 5.1 and 24.3 nM, respectively) and is selective for mGluR2 and mGluR3...
Schlagworte: | (1S,2S,5R,6S)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
Anwendung: | mGluR2 / mGluR3 agonist |
CAS | 176199-48-7 |
MW: | 185.2 D |
ab 44,00 €
Artikelnummer: Cay78020-50
ACPT-II is a general competitive antagonist of metabotropic glutamate (mGlu) receptors. The KB values for mGlu1a, mGlu2, and mGlu4a receptors are 115, 88, and 77 µM, respectively. It binds to the large extracellular domain called a Venus flytrap module, where agonists bind. ACPT-II is a stereoisomer of the group III...
Schlagworte: | 4-amino-1alpha,2alpha,4beta-cyclopentanetricarboxylic acid |
Anwendung: | Competitive metabotropic glutamate (mGlu) receptor antagonist |
CAS | 195209-04-2 |
MW: | 217.2 D |
ab 60,00 €
Artikelnummer: Cay14626-1
CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2. It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 µM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well...
Schlagworte: | N,N'-(1,4-phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide |
Anwendung: | GluR2 positive allosteric modulator |
CAS | 380607-77-2 |
MW: | 376.5 D |
ab 50,00 €
Artikelnummer: Cay21984-1
JNJ-42153605 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGluR2, EC50 = 17 nM in CHO cells expressing the human receptor). In vivo, JNJ-42153605 (3 mg/kg) inhibits mGluR2-mediated rapid eye movement (REM) sleep in rats. It also reverses phencyclidine-induced hyperlocomotion in mice (ED50...
Schlagworte: | 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine |
Anwendung: | Positive allosteric mGlu2 receptor modulator |
CAS | 1254977-87-1 |
MW: | 400.4 D |
ab 50,00 €