Ingliforib

Ingliforib is an inhibitor of the liver, muscle, and brain forms of glycogen phosphorylase (IC50s = 52, 352, and 150 nM, respectively). It decreases myocardial glycogen phosphorylase activity and infarct size as a percentage of the area at risk in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion.Formal Name: 5-chloro-N-[(1S,2R)-3-[(3R,4S)-3,4-dihydroxy-1-,wbr/>pyrrolidinyl]-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide. CAS Number: 186392-65-4. Synonyms: CP 368,296. Molecular Formula: C23H24ClN3O5. Formula Weight: 457.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 212, 298 nm. SMILES: ClC1=CC=C2NC(C(N[C@H]([C@H](C(N3C[C@@H]([C@@H](C3)O)O)=O)O)CC4=CC=CC=C4)=O)=CC2=C1. InChi Code: InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3-5-13)21(30)23(32)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8,11-12H2,(H,26,31)/t17-,19-,20+,21+/m0/s1. InChi Key: GVDRRZOORHCTAN-MJUUVYJYSA-N.