ICEC0942 (hydrochloride)

ICEC0942 is a cyclin-dependent kinase 7 (Cdk7) inhibitor (IC50 = 0.04 µM). It is selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively). ICEC0942 induces cell cycle arrest at the G2/M phase and apoptosis in HCT116 cells when used at concentrations of 1 and 10 µM. In vivo, ICEC0942 (100 mg/kg) reduces tumor growth in MCF-7 and HCT116 mouse xenograft models.Formal Name: (3R,4R)-4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-3-piperidinol, monohydrochloride. CAS Number: 1805789-54-1. Molecular Formula: C22H30N6O . HCl. Formula Weight: 431.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 245 nm. SMILES: O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C=NN3C(NCC4=CC=CC=C4)=C2)C(C)C.Cl. InChi Code: InChI=1S/C22H30N6O.ClH/c1-15(2)18-13-26-28-21(25-11-16-6-4-3-5-7-16)10-20(27-22(18)28)24-12-17-8-9-23-14-19(17)29,/h3-7,10,13,15,17,19,23,25,29H,8-9,11-12,14H2,1-2H3,(H,24,27),1H/t17-,19+,/m1./s1. InChi Key: YMNPLAHCOLEZJE-ZFNKBKEPSA-N.