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Zu "K02202" wurden 71 Artikel gefunden!
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Artikelnummer: A300-405A
Protein function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2...
Schlagworte: | Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,... |
Anwendung: | WB, IP, IHC, ICC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse, rat |
ab 164,00 €
Artikelnummer: Cay9002215-1
THZ1 is a Cdk7 inhibitor (IC50s = 3.2-15.6 nM in vitro) that selectively targets a remote cysteine residue located outside of the classic kinase domain. THZ1 also targets Cdk12 kinase activity although at a higher concentration (IC50 = 250 nM). It displays broad anti-proliferative activity against cancer cell lines,...
Schlagworte: | N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-benzamide |
Anwendung: | CDK7 inhibitor |
CAS | 1604810-83-4 |
MW: | 566.1 D |
ab 48,00 €
Artikelnummer: Cay26024-5
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively). It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM. Flavopiridol inhibits transcription of a CMV promoter in HeLa...
Schlagworte: | Alvocidib, HL 275, HMR 1275, L-868,275,... |
Anwendung: | Cyclin dependent kinase inhibitor |
CAS | 146426-40-6 |
MW: | 401.8 D |
ab 77,00 €
Artikelnummer: Cay17904-5
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity...
Schlagworte: | BMS-387032, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide |
Anwendung: | Cdk9 / Cdk2 / Cdk7 inhibitor |
CAS | 345627-80-7 |
MW: | 380.5 D |
ab 60,00 €
Artikelnummer: Cay23398-1
LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7, IC50 = 50s = >10, >10, and 1.71 µM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human...
Schlagworte: | 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
Anwendung: | CDK7 inhibitor |
CAS | 1453834-21-3 |
MW: | 432.5 D |
ab 50,00 €
Artikelnummer: Cay17996-10
BS-181 is a Cdk7 inhibitor that blocks the activity of Cdk-activating kinase with an IC50 value of 21 nM. It inhibits Cdk2 at a concentration 35-fold higher than that of Cdk7. BS-181 has been shown to inhibit the phosphorylation of Cdk7 substrates, to promote cell cycle arrest and apoptosis, to inhibit the growth of...
Schlagworte: | N5-(6-aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)-pyrazolo[1,5-alpha]pyrimidine-5,7-diamine, monohydrochloride |
Anwendung: | CDK7 inhibitor |
CAS | 1397219-81-6 |
MW: | 417 D |
ab 60,00 €
Artikelnummer: Cay30997-1
ICEC0942 is a cyclin-dependent kinase 7 (Cdk7) inhibitor (IC50 = 0.04 µM). It is selective for Cdk7 over Cdk1, -2, -4, -5, -6, and -9 (IC50s = 1.8, 0.62, 49, 9.4, 34, and 1.2 µM, respectively). ICEC0942 induces cell cycle arrest at the G2/M phase and apoptosis in HCT116 cells when used at concentrations of 1 and 10...
Schlagworte: | (3R,4R)-4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-3-piperidinol,... |
Anwendung: | Cdk7 inhibitor |
CAS | 1805789-54-1 |
MW: | 431 D |
ab 62,00 €
Artikelnummer: A700-006
Protein function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2...
Schlagworte: | Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,... |
Anwendung: | WB, IP, IHC, ICC, FC |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
ab 172,00 €
Artikelnummer: G-HUFI02303.96
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
641,00 €
Artikelnummer: NSJ-R31240
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyclin-dependent kinase 7, also known as Cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. The gene was assigned to human...
Schlagworte: | Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, rat, mouse |
755,00 €
Artikelnummer: NSJ-R31241
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyclin-dependent kinase 7, also known as cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase(CDK) family. The gene was assigned to human...
Schlagworte: | Anti-Cak, Anti-Cdk7, Anti-CRK4, Anti-P39 Mo15, EC=2.7.11.22, EC=2.7.11.23, Anti-CR4 protein kinase, Anti-39 kDa protein... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, rat, mouse |
755,00 €
Artikelnummer: NSJ-R32121
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cyclin-dependent kinase 7, also known as cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. The gene was assigned to human...
Schlagworte: | Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.23, EC=2.7.11.22, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1,... |
Anwendung: | WB |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
755,00 €