HR68

HR68 is an anticancer agent and a derivative of the peroxisome proliferator-activated receptor (PPAR) agonist fenofibric acid (Cay-19262). It decreases the viability of LN-229 glioblastoma cells (IC50 = 1.17 µM). HR68 crosses the blood-brain barrier in a temozolomide-resistant orthotopic patient-derived xenograft (PDX) mouse model of glioblastoma.Formal Name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-N-4-pyridinyl-propanamide. CAS Number: 2454582-64-8. Synonyms: PP21. Molecular Formula: C22H19ClN2O3. Formula Weight: 394.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Chloroform: Soluble, Methanol: Soluble. SMILES: CC(C(NC1=CC=NC=C1)=O)(OC2=CC=C(C(C3=CC=C(C=C3)Cl)=O)C=C2)C. InChi Code: InChI=1S/C22H19ClN2O3/c1-22(2,21(27)25-18-11-13-24-14-12-18)28-19-9-5-16(6-10-19)20(26)15-3-7-17(23)8-4-15/h3-14H,1-2H3,(H,24,25,27). InChi Key: UUBDTDNTOJQKPE-UHFFFAOYSA-N.