Zu "K07294" wurden 99 Artikel gefunden!

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KRP 297
KRP 297

Artikelnummer: Cay33699-1

KRP 927 is a thiazolidinedione dual agonist of PPARalpha and PPARgamma (EC50s = 149 and 83 nM, respectively, in transactivation assays). It decreases hyperglycemia and hyperinsulinemia in ob/ob mice in a dose-dependent manner. KRP 927 (10 or 30 mg/kg) reduces serum total cholesterol and triglyceride levels in...
Schlagworte: MK-767, 5-[(2,4-dioxo-5-thiazolidinyl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]-benzamide
Anwendung: PPARalpha / PPARgamma dual agonist
CAS 213252-19-8
MW: 438.4 D
ab 74,00 €
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Pemafibrate, Free Acid
Pemafibrate, Free Acid

Artikelnummer: LC-P-5115_100mg

Soluble in DMSO.
Schlagworte: K-877, R-K-13675
Anwendung: Antihyperlipidemic, Triglyceride synthesis inhibitor, PPAR alpha agonist
CAS 848259-27-8
MW: 490.55 D
ab 76,00 €
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GW7647, Free Acid
GW7647, Free Acid

Artikelnummer: LC-G-1111_100mg

Soluble in DMSO. GW7647 is a peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist. A synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and GW7647 was demonstrated in a model of acute chemical-induced pain. Russo R., et al. 'Synergistic...
Anwendung: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
CAS 265129-71-3
MW: 502.75 D
ab 68,00 €
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GW590735, Free Acid
GW590735, Free Acid

Artikelnummer: LC-G-7322_100mg

Soluble in DMSO. GW590735 is a potent and selective PPARalpha agonist. It stimulated PPARalpha with an EC50 of 4 nM and had at least 500-fold selectivity on PPARalpha versus PPARdelta and PPARgamma. It raised circulating levels of high-density lipoprotein cholesterol. Sierra M.L., et al. 'Substituted...
Anwendung: Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist
CAS 622402-22-6
MW: 478.48 D
ab 90,00 €
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Anti-PPARA
Anti-PPARA

Artikelnummer: E-AB-67328.120

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers, this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for...
Schlagworte: Anti-PPARA, Anti-NR1C1, Anti-PPAR-alpha, Anti-Nuclear receptor subfamily 1 group C member 1, Anti-Peroxisome...
Anwendung: WB
Reaktivität: Human, Mouse
ab 117,00 €
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Gemfibrozil-d6
Gemfibrozil-d6

Artikelnummer: Cay31915-1

Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil (Cay-14835) by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma agonist (EC50s = 193.3 and 147.8 µM, respectively, in transactivation assays). In vivo, gemfibrozil...
Schlagworte: CI-719-d6, 5-(2,5-dimethylphenoxy)-2,2-di(methyl-d3)-pentanoic acid
Anwendung: GC-MS, LC-MS, Internal standard, Quantification, PPAR alpha activator
CAS 1184986-45-5
MW: 256.4 D
ab 74,00 €
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CAY10767
CAY10767

Artikelnummer: Cay30605-1

CAY10767 is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha, EC50 = 37 nM in a reporter assay). It is greater than 2,700-fold selective for PPARalpha over PPARgamma or PPARdelta. Formal Name: 3-[[[4-[(4-fluorophenyl)methoxy]-3-methylphenyl]methyl]amino]-benzoic acid. CAS Number:...
Schlagworte: 3-[[[4-[(4-fluorophenyl)methoxy]-3-methylphenyl]methyl]amino]-benzoic acid
Anwendung: Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist
CAS 2376590-40-6
MW: 365.4 D
ab 62,00 €
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GW 6471
GW 6471

Artikelnummer: Cay11697-1

The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation. GW 6471 is an antagonist of PPARalpha (IC50 = 240 nM). It drives the displacement of coactivators...
Schlagworte: N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)e...
Anwendung: PPARalpha antagonist
CAS 880635-03-0
MW: 619.7 D
ab 44,00 €
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Fenofibrate
Fenofibrate

Artikelnummer: Cay10005368-1

Fenofibrate is an agonist of peroxisome proliferator-activated receptor alpha (PPARalpha) with EC50 values of 18 and 30 µM for mouse and human receptors, respectively, in a transactivation assay. It is selective for PPARalpha over PPARgamma (EC50s = 300 and 200 µM for mouse and human receptors, respectively) and...
Schlagworte: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester
Anwendung: PPARalpha agonist
CAS 49562-28-9
MW: 360.8 D
ab 12,00 €
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PPARalpha Transcription Factor Assay Kit
PPARalpha Transcription Factor Assay Kit

Artikelnummer: Cay10006915-96

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the large family of nuclear hormone receptors. There are three subtypes, PPARalpha, beta/delta, and gamma, which are expressed at variable levels in different tissues. The Cayman Chemical PPARalpha...
Schlagworte: Peroxisome Proliferator-activated Receptor alpha Transcription Factor Assay Kit
Anwendung: PPAR binding detection
Reaktivität: Human
532,00 €
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Wy 14643
Wy 14643

Artikelnummer: Cay70730-5

Wy 14643 is a peroxisome proliferator-activated receptor (PPAR activator). Although this compound is primarily an activator of PPARalpha, it activates PPARgamma as well. Activation of PPARdelta by Wy 14643 is also observed, but this finding is rare. The potency of Wy 14643 as an activator of PPARalpha is species...
Schlagworte: Pirinixic Acid, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid
Anwendung: PPAR activator
CAS 50892-23-4
MW: 323.8 D
ab 12,00 €
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GW 7647
GW 7647

Artikelnummer: Cay10008613-1

Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a ligand-activated transcription factor involved in the regulation of lipid homeostasis. Activation of PPARalpha results in expression of a variety of genes, particularly those involved in fatty acid beta-oxidation, binding, and transport. GW 7647 is a...
Schlagworte: 2-methyl-2-[[4-[2-[[(cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-propanoic acid
Anwendung: PPARalpha agonist
CAS 265129-71-3
MW: 502.8 D
ab 37,00 €
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