HM61713

HM61713 is an inhibitor of mutant EGFR (IC50 = 0.01 µM for EGFRT790M/L858R). It is selective for EGFRT790M/L858R over PI3Kalpha (IC50 = >10 µM). HM61713 is cytotoxic to A549, H1975, and H460 lung and MCF-7 breast cancer cells (IC50s = 4.29, 0.52, 5.29, and 26.9 µM, respectively). It reduces tumor growth in an ETS1-overexpressing doxorubicin-resistant K562 leukemia mouse xenograft model when administered at a dose of 30 mg/kg in combination with doxorubicin.Formal Name: N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide. CAS Number: 1353550-13-6. Synonyms: BI-1482694, Olmutinib. Molecular Formula: C26H26N6O2S. Formula Weight: 486.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 44 mg/mL. SMILES: CN1CCN(C2=CC=C(NC3=NC(OC4=CC=CC(NC(C=C)=O)=C4)=C(SC=C5)C5=N3)C=C2)CC1. InChi Code: InChI=1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30). InChi Key: FDMQDKQUTRLUBU-UHFFFAOYSA-N.