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Zu "K07370" wurden 129 Artikel gefunden!
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Artikelnummer: Cay30165-1
ARQ 531 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 0.85 nM). It reduces the viability of, and inhibits BTK autophosphorylation in, OCI-AML-2 acute myeloid leukemia (AML) cells when used at concentrations of 0.3 and 1 µM. In vivo, ARQ 531 (75 mg/kg) reduces tumor growth in an SU-DHL-4 B cell lymphoma...
Schlagworte: | MK-1026, Nemtabrutinib,... |
Anwendung: | BTK inhibitor |
CAS | 2095393-15-8 |
MW: | 478.9 D |
ab 34,00 €
Artikelnummer: Cay36581-25
MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (Cay-16274) linked to the cereblon inhibitor pomalidomide (Cay-19877). It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK...
Schlagworte: | 2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-p... |
Anwendung: | BTK degradation driving PROTAC |
CAS | 2231744-29-7 |
MW: | 787.8 D |
ab 57,00 €
Artikelnummer: ELK-ELK2680.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Btk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Btk. Next,...
Schlagworte: | BPK, BTK, ATK, AGMX1, Bruton tyrosine kinase, B-cell progenitor kinase, Tyrosine-protein kinase BTK, Agammaglobulinemia... |
Anwendung: | ELISA |
Spezies-Reaktivität: | human |
ab 365,00 €
Artikelnummer: ELK-ELK5122.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Btk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Btk. Next,...
Schlagworte: | BPK, Bpk, ATK, Btk, Kinase EMB, EC=2.7.10.2, Bruton tyrosine kinase, B-cell progenitor kinase, Tyrosine-protein kinase... |
Anwendung: | ELISA |
Spezies-Reaktivität: | mouse |
ab 365,00 €
Artikelnummer: Cay16274-1
Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation,...
Schlagworte: | Imbruvica, PCI 32765, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
Anwendung: | BTK inhibitor |
CAS | 936563-96-1 |
MW: | 440.5 D |
ab 50,00 €
Artikelnummer: Cay37723-10
Tolebrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 1 nM). It decreases the number of CD69+ B cells in isolated mouse whole blood (IC50 = 200 nM).Formal Name: 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one. CAS...
Schlagworte: | 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one |
Anwendung: | Irreversible BTK inhibitor |
CAS | 1971920-73-6 |
MW: | 455.5 D |
ab 90,00 €
Artikelnummer: NSJ-F52632-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma...
Schlagworte: | Anti-BPK, Anti-ATK, Anti-BTK, Anti-AGMX1, EC=2.7.10.2, Anti-Bruton tyrosine kinase, Anti-B-cell progenitor kinase,... |
Anwendung: | WB, ELISA |
Wirt: | Rabbit |
Spezies-Reaktivität: | human, mouse |
ab 326,00 €
Artikelnummer: LKT-P0932.1
PCI-32765 is an irreversible inhibitor of Bruton's tyrosine kinase (BTK), an enzyme that plays a significant role in B-cell receptor signaling and B-cell malignancies and autoimmune diseases such as x-linked agammaglobulinemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. PCI-32765's inhibition of BTK...
Schlagworte: | Ibrutinib |
Anwendung: | Bruton's tyrosine kinase inhibitor |
CAS | 936563-96-1 |
MW: | 440.5 D |
ab 99,00 €
Artikelnummer: LKT-A8644.25
AVL-292 is a Bruton's tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).
Schlagworte: | CC-292 |
Anwendung: | BTK inhibitor |
CAS | 1202757-89-8 |
MW: | 423.44 D |
ab 90,00 €
Artikelnummer: AG-CR1-3620-M025
White solid. Soluble in DMSO. Slightly soluble in ethanol (1mg/ml). Insoluble in water. Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity, Binds to and irreversibly inhibits BTK activity, preventing...
Schlagworte: | PCI-32765 |
Anwendung: | BTK inhibitor |
CAS | 936563-96-1 |
MW: | 440,5 D |
ab 88,00 €
Artikelnummer: Cay18924-1
ONO-4059 analog is a derivative of the Bruton's tyrosine kinase (BTK) inhibitor ONO-4059 (Cay-32957).Formal Name: 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one. CAS Number: 1351635-67-0. Synonyms: GS-4059 analog. Molecular Formula: C25H24N6O3. Formula Weight:...
Schlagworte: | GS-4059 analog, 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one |
Anwendung: | BTK inhibitor |
CAS | 1351635-67-0 |
MW: | 456.5 D |
ab 60,00 €
Artikelnummer: Cay19481-1
HM61713 is an inhibitor of mutant EGFR (IC50 = 0.01 µM for EGFRT790M/L858R). It is selective for EGFRT790M/L858R over PI3Kalpha (IC50 = >10 µM). HM61713 is cytotoxic to A549, H1975, and H460 lung and MCF-7 breast cancer cells (IC50s = 4.29, 0.52, 5.29, and 26.9 µM, respectively). It reduces tumor growth in an...
Schlagworte: | BI-1482694, Olmutinib,... |
Anwendung: | BTK inhibitor |
CAS | 1353550-13-6 |
MW: | 486.6 D |
ab 43,00 €