Zu "K07370" wurden 163 Artikel gefunden!
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BTK Protein, Human, Recombinant (His)
Artikelnummer: TGM-TMPH-02271-10ug
Description: Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2...
| Schlagworte: | BPK , B-cell progenitor kinase (BPK) , Tyrosine-protein kinase BTK , AGMX1 , Bruton tyrosine kinase , ATK , BTK ,... |
| MW: | 78.3 kD |
ab 112,00 €
Tolebrutinib
Artikelnummer: Cay37723-10
Tolebrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 1 nM). It decreases the number of CD69+ B cells in isolated mouse whole blood (IC50 = 200 nM).Formal Name: 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one. CAS...
| Schlagworte: | 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one |
| Anwendung: | Irreversible BTK inhibitor |
| CAS | 1971920-73-6 |
| MW: | 455.5 D |
ab 107,00 €
Remibrutinib
Artikelnummer: Cay44962-10
Remibrutinib is a covalent inhibitor of Bruton's tyrosine kinase (BTK. IC50 = 1. nM). It selectively binds to BTK over bone marrow tyrosine kinase on chromosome X (BMX) and Tec (Kds = 0. 540, and 110 nM, respectively), as well as IL-2-inducible T cell kinase (Itk), EGFR, HER2, HER4, and JAK3 (Kds = >10,000 nM for...
| Schlagworte: | LOU064,... |
| Anwendung: | BTK inhibitor |
| CAS | 1787294-07-8 |
| MW: | 507.54 D |
ab 97,00 €
Ibrutinib
Artikelnummer: Cay16274-1
Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation,...
| Schlagworte: | Imbruvica, PCI 32765, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one |
| Anwendung: | BTK inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 58,00 €
Ibrutinib
Artikelnummer: AG-CR1-3620-M005
White solid. Soluble in DMSO. Slightly soluble in ethanol (1mg/ml). Insoluble in water. Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity, Binds to and irreversibly inhibits BTK activity, preventing...
| Schlagworte: | PCI-32765 |
| Anwendung: | BTK inhibitor |
| CAS | 936563-96-1 |
| MW: | 440,5 D |
ab 88,00 €
Anti-BTK
Artikelnummer: NSJ-F52632-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma...
| Schlagworte: | Anti-BPK, Anti-ATK, Anti-BTK, Anti-AGMX1, EC=2.7.10.2, Anti-Bruton tyrosine kinase, Anti-B-cell progenitor kinase,... |
| Anwendung: | WB, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 361,00 €
PCI-32765
Artikelnummer: LKT-P0932.1
PCI-32765 is an irreversible inhibitor of Bruton's tyrosine kinase (BTK), an enzyme that plays a significant role in B-cell receptor signaling and B-cell malignancies and autoimmune diseases such as x-linked agammaglobulinemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. PCI-32765's inhibition of BTK...
| Schlagworte: | Ibrutinib |
| Anwendung: | Bruton's tyrosine kinase inhibitor |
| CAS | 936563-96-1 |
| MW: | 440.5 D |
ab 104,00 €
Acalabrutinib
Artikelnummer: Cay19899-5
Acalabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK). It can dose-dependently inhibit B cell receptor signaling in primary chronic lymphocytic leukemia cells. In kinase-inhibition assays, acalabrutinib was more selective than ibrutinib (Cay-16274) for inhibiting BTK and did not inhibit EGFR,...
| Schlagworte: | ACP-196, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide |
| Anwendung: | BTK inhibitor |
| CAS | 1420477-60-6 |
| MW: | 465.5 D |
ab 51,00 €
CGI1746
Artikelnummer: Cay18414-5
CGI1746 is a potent, selective inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 1.9 nM), a non-receptor tyrosine kinase that is important in B lymphocyte development. It blocks both auto-and trans-phosphorylation of BTK by occupying an SH3 binding pocket in the un-phosphorylated enzyme. CGI1746 prevents B-cell...
| Schlagworte: | N-[3-[4,5-dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylet... |
| Anwendung: | Btk inhibitor |
| CAS | 910232-84-7 |
| MW: | 579.7 D |
ab 45,00 €
AVL-292
Artikelnummer: LKT-A8644.25
AVL-292 is a Bruton's tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).
| Schlagworte: | CC-292 |
| Anwendung: | BTK inhibitor |
| CAS | 1202757-89-8 |
| MW: | 423.44 D |
ab 94,00 €
Zanubrutinib
Artikelnummer: Cay28924-1
Zanubrutinib is a potent and covalent inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 0.3 nM). It is selective for BTK over a panel of 304 kinases at 1 µM but does inhibit EGFR, Tec, Blk, BMX, HER4, and TXK (IC50s = 0.62-33 nM). Zanubrutinib inhibits phosphorylation of BTK at Y233 (IC50 = 1.8 nM) in Ramos cells...
| Schlagworte: | BGB-3111,... |
| Anwendung: | Potent covalent BTK (Bruton's tyrosine kinase ) inhibitor |
| CAS | 1691249-45-2 |
| MW: | 471.6 D |
ab 97,00 €
ONO-4059 analog
Artikelnummer: Cay18924-1
ONO-4059 analog is a derivative of the Bruton's tyrosine kinase (BTK) inhibitor ONO-4059 (Cay-32957).Formal Name: 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one. CAS Number: 1351635-67-0. Synonyms: GS-4059 analog. Molecular Formula: C25H24N6O3. Formula Weight:...
| Schlagworte: | GS-4059 analog, 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one |
| Anwendung: | BTK inhibitor |
| CAS | 1351635-67-0 |
| MW: | 456.5 D |
ab 69,00 €