Hemin chloride

Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2alpha kinase 1 (eIF2alphaK1), a repressor of eIF-2alpha. This alters the initiation of mRNA translation, evoking a wide array of cellular effects. Hemin chloride is used experimentally to induce the expression of heme oxygenase-1 in cells and in animals. Heme extracted from blood is usually oxidized to hemin chloride. In porphyria, disorders resulting from an increase in porphyrins, hemin chloride serves to activate feedback inhibition of delta-aminolevulinic acid synthase, reducing heme biosynthesis.Formal Name: (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,8-dipropanoato(4-)-kappaN21, kappaN22, kappaN23, kappaN24]-ferrate(2-), dihydrogen. CAS Number: 16009-13-5. Molecular Formula: C34H30ClFeN4O4 . 2H. Formula Weight: 652.0. Purity: >96%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 397 nm. SMILES: [O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Fe+3]35([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]. InChi Code: InChI=1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25,,/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42),1H,/q,,+3/p-3/b25-13-,26-13-,2. InChi Key: BTIJJDXEELBZFS-HXFTUNQESA-K.