GW 766994

GW 766994 is an antagonist of chemokine (C-C motif) receptor 3 (CCR3) with a Ki value of 13.8 nM in an assay of eosinophil chemotaxis induced by chemokine (C-C motif) ligand 11 (CCL11). It decreases CCL11-induced cyclin-dependent kinase 5 (Cdk5) and tau phosphorylation and production of amyloid beta (1-42) (Abeta42) in isolated mouse hippocampal neurons when used at a concentration of 10 µM.Formal Name: 4-[[[[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]-benzamide. CAS Number: 408303-43-5. Synonyms: GW 994. Molecular Formula: C21H24Cl2N4O3. Formula Weight: 451.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 225 nm. SMILES: ClC1=C(Cl)C=C(CN2C[C@H](CNC(NCC3=CC=C(C(N)=O)C=C3)=O)OCC2)C=C1. InChi Code: InChI=1S/C21H24Cl2N4O3/c22-18-6-3-15(9-19(18)23)12-27-7-8-30-17(13-27)11-26-21(29)25-10-14-1-4-16(5-2-14)20(24)28/h1-6,9,17H,7-8,10-13H2,(H2,24,28)(H2,25,26,29)/t17-/m0/s1. InChi Key: GPLUUMAKBFSDIE-KRWDZBQOSA-N.