Gosogliptin

Gosogliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 0.013 µM). It is selective for DPP-4 over DPP-2, -3, -8, and -9 (IC50s = 3.3, >30, 7, and 5.98 µM, respectively), the serine proteases APP, FAP, and POP (IC50s = >30, 10.3, and >30 µM, respectively), and a panel of enzymes, receptors, and ion channels (IC50s = >10 µM for all).Formal Name: (3,3-difluoro-1-pyrrolidinyl)[(2S,4S)-4-[4-(2-pyrimidinyl)-1-piperazinyl]-2-pyrrolidinyl]-methanone. CAS Number: 869490-23-3. Synonyms: PF 734200. Molecular Formula: C17H24F2N6O. Formula Weight: 366.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: [H][C@@]1(N2CCN(C3=NC=CC=N3)CC2)CN[C@H](C(N4CC(F)(F)CC4)=O)C1. InChi Code: InChI=1S/C17H24F2N6O/c18-17(19)2-5-25(12-17)15(26)14-10-13(11-22-14)23-6-8-24(9-7-23)16-20-3-1-4-21-16/h1,3-4,13-14,22H,2,5-12H2/t13-,14-/m0/s1. InChi Key: QWEWGXUTRTXFRF-KBPBESRZSA-N.