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DPP-4/CD26 Extracellular Domain (human, recombinant)
DPP-4/CD26 Extracellular Domain (human, recombinant)

Artikelnummer: Cay31848-10

Dipeptidyl peptidase 4 (DPP-4), also known as CD26, is a type II transmembrane glycoprotein with a major role in glucose metabolism. It is composed of a short cytoplasmic tail, a transmembrane domain, and a large extracellular domain, which contains a flexible stalk, glycosylation- and cysteine-rich regions, and a...
Schlagworte: CD26, ADCP2, ADABP, TP103, ADCP-2, DPP IV, Dipeptidyl peptidase IV, T-cell activation antigen CD26, Dipeptidyl peptidase 4...
ab 249,00 €
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Gosogliptin
Gosogliptin

Artikelnummer: Cay33220-1

Gosogliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 0.013 µM). It is selective for DPP-4 over DPP-2, -3, -8, and -9 (IC50s = 3.3, >30, 7, and 5.98 µM, respectively), the serine proteases APP, FAP, and POP (IC50s = >30, 10.3, and >30 µM, respectively), and a panel of enzymes, receptors, and ion...
Schlagworte: PF 734200, (3,3-difluoro-1-pyrrolidinyl)[(2S,4S)-4-[4-(2-pyrimidinyl)-1-piperazinyl]-2-pyrrolidinyl]-methanone
Anwendung: DPP4 inhibitor
CAS 869490-23-3
MW: 366.4 D
ab 312,00 €
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DPP (IV) Inhibitor Screening Assay Kit
DPP (IV) Inhibitor Screening Assay Kit

Artikelnummer: Cay700210-96

DPP (IV) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by DPP (IV). GLP-1 extends the action of insulin while suppressing the release...
Schlagworte: Dipeptidyl peptidase IV
Anwendung: DPP (IV) inhibitor screening
Reaktivität: Human
375,00 €
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Sitagliptin (phosphate)
Sitagliptin (phosphate)

Artikelnummer: Cay13252-50

(-)-Sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 18 nM). It is selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases, including DPP-9, DPP-2, and amino peptidase P. (-)-Sitagliptin improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet...
Schlagworte: (R)-Sitagliptin, INN, MK-431, ONO-5435,...
Anwendung: DPP4 inhibitor
CAS 654671-78-0
MW: 505.3 D
ab 37,00 €
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DPP4, active human recombinant protein
DPP4, active human recombinant protein

Artikelnummer: BPS-80040

Active human DPP4 (GenBank Accession No. NM_001935), (amino acids 29-end) with C-terminal His tag, MW=89.1 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Schlagworte: CD26, DPP4, ADCP2, ADABP, TP103, ADCP-2, DPP IV, EC=3.4.14.5, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, T-cell...
Anwendung: Enzyme kinetics, inhibitor screening
MW: 89.1 kD
549,00 €
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Linagliptin
Linagliptin

Artikelnummer: AG-CR1-3618-M050

White to off-white solid. Soluble in DMSO, ethanol or methanol. Slightly soluble in water (~1mg/ml). Antidiabetic agent, Highly potent and selective competitive inhibitor of dipeptidyl-peptidase 4 (DPP4, DPP IV, CD26), an enzyme that degrades, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic...
Schlagworte: 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione, BI-1356
Anwendung: Antidiabetic agent, DPP4 inhibitor
CAS 668270-12-0
MW: 472,5 D
ab 50,00 €
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Vildagliptin
Vildagliptin

Artikelnummer: Cay14705-10

Glyptins are a class of oral antihyperglycemic agents that inhibit dipeptidyl peptidase 4 (DPP-4), which can act as a serine exopeptidase. In addition to having use in type 2 diabetes, gliptins have positive cardiovascular and anti-inflammatory effects. Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM). It...
Schlagworte: 1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2S-pyrrolidinecarbonitrile
Anwendung: DPP4 / DPP8 / DPP9 inhibitor
CAS 274901-16-5
MW: 303.4 D
ab 32,00 €
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Mouse CD26 - DPP4 ELISA Kit
Mouse CD26 - DPP4 ELISA Kit

Artikelnummer: KOA0402

Natural and recombinant mouse CD26. There is no detectable cross-reactivity with other relevant proteins. Protein function: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by...
Schlagworte: Dpp4, Cd26
Anwendung: ELISA
Reaktivität: Mouse
673,00 €
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Saxagliptin (hydrochloride)
Saxagliptin (hydrochloride)

Artikelnummer: Cay23697-1

Saxagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4, Ki = 0.6 nM). It inhibits DPP-4 ex vivo (ED50 = 0.12 µmol/kg) in plasma from normal fasted rats. Saxagliptin (0.3-3 mg/kg) reduces plasma glucose levels in Zuckerfa/fa diabetic rats in a dose-dependent manner. Oral administration at doses ranging...
Schlagworte: BMS-477118,...
Anwendung: Dipeptidyl peptidase-4 (DPP-4) inhibitor
CAS 709031-78-7
MW: 351.9 D
ab 37,00 €
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DPP4 assay kit
DPP4 assay kit

Artikelnummer: BPS-80204

The DPP4 Fluorescent Activity Assay kit is designed to measure DPP4 activity using purified DPP4 or DPP4 extracts. It comes in a convenient 96-well format, with purified DPP4 enzyme, DPP4 substrate, and DPP4 assay buffer for 100 enzyme reactions. The key to DPP4 Fluorescent Activity Assay is the fluorogenic...
Schlagworte: CD26, DPP4, ADCP2, ADABP, TP103, ADCP-2, DPP IV, EC=3.4.14.5, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, T-cell...
Anwendung: DPP4 assays, Inhibitor screening, HTS
587,00 €
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Diprotin A
Diprotin A

Artikelnummer: Cay28014-10

Diprotin A is a tripeptide inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 1.1 µg/ml). It inhibits degradation of glucagon-like peptide 1 (GLP-1, Cay-24460) in culture with insulin-secreting BRIN-BD11 rat pancreatic beta-cells when used at a concentration of 25 µM. Diprotin A (5 mg/ml) pre-incubation enhances...
Schlagworte: Ile-Pro-Ile, L-isoleucyl-L-prolyl-L-isoleucine
Anwendung: DPP4 inhibitor
CAS 90614-48-5
MW: 341.5 D
ab 57,00 €
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Alogliptin (benzoate salt)
Alogliptin (benzoate salt)

Artikelnummer: Cay23768-50

Alogliptin is an orally bioavailable dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, fibroblast activation protein (FAP), and tryptase (IC50s = >100,000 nM). It does not inhibit cytochrome P450 enzymes and does not block the human...
Schlagworte: SYR-322, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile,...
Anwendung: DPP-4 inhibitor
CAS 850649-62-6
MW: 461.5 D
ab 55,00 €
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