(±)-Flurbiprofen

(±)-Flurbiprofen is a non-selective COX inhibitor (IC50s = 0.04 and 0.51 µM for COX-1 and COX-2, respectively). In vivo, (±)-flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats. (±)-Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg. Formulations containing (±)-flurbiprofen have been used to manage pain and inflammation associated with arthritis.Formal Name: (±)-2-fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetic acid. CAS Number: 5104-49-4. Synonyms: Ansaid. Molecular Formula: C15H13FO2. Formula Weight: 244.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 25 mg/ml, PBS pH 7.2: .5 mg/ml. lambdamax: 247 nm. SMILES: OC(=O)C(C)c1ccc(c2ccccc2)c(F)c1. InChi Code: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18). InChi Key: SYTBZMRGLBWNTM-UHFFFAOYSA-N.