Dooku1

Dooku1 is an antagonist of yoda1-activated Piezo1 ion channels (IC50 = 1.3 µM in HEK293 cells expressing the human receptor). It is selective for Piezo1 activated by yoda1 (Cay-21904) over constituitively active Piezo1, transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential canonical 4 (TRPC4) at 10 µM. Dooku1 (10 µM) reduces the percentage of cells with yoda1-induced extracellular phosphatidylserine exposure in red blood cells (RBCs) isolated from patients with sickle cell anemia. Preincubation with dooku1 (10 µM) inhibits yoda1-induced relaxation of isolated mouse aortic rings.Formal Name: 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole. CAS Number: 2253744-54-4. Molecular Formula: C13H9Cl2N3OS. Formula Weight: 326.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 296 nm. SMILES: ClC1=CC=CC(Cl)=C1CSC2=NN=C(C3=CC=CN3)O2. InChi Code: InChI=1S/C13H9Cl2N3OS/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11/h1-6,16H,7H2. InChi Key: MNPOBXLPCWFONX-UHFFFAOYSA-N.