Zu "K22128" wurden 27 Artikel gefunden!
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Yaddle1
Artikelnummer: Cay43431-10
Yaddle1 is an agonist of Piezo1 and a derivative of Yoda1 (Cay-21904). It induces calcium influx in a reporter assay using HEK293A cells expressing human Piezo1 (EC50 = 0.4 µM). Yaddle1 (15 µM) induces calcium influx in primary human CD4+ T cells, which express Piezo1, and does not decrease the viability of isolated...
| Schlagworte: | 2-[5-[[[2-chloro-6-(trifluoromethyl)phenyl]methyl]thio]-1,3,4-oxadiazol-2-yl]-pyrazine |
| Anwendung: | Piezo1 agonist |
| CAS | 3041134-13-5 |
| MW: | 372.75 D |
ab 161,00 €
Yoda2 (potassium salt)
Artikelnummer: Cay43639-1
A Piezo1 agonist, induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 150 nM), selective for Piezo1 over 30 other ion channels and receptors at 5 µM, induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50 = 1.2 µM), increases cortical area and thickness at 15 and 37%...
| Schlagworte: | KC289, 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate, monopotasium salt |
| Anwendung: | Piezo1 agonist |
| MW: | 435.38 D |
ab 68,00 €
Yoda1
Artikelnummer: Cay21904-1
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 µM for murine and human Piezo1-transfected HEK293T cells, respectively). It is selective for Piezo1 as it elicits Ca2+ flux in Piezo1- but not Piezo2-transfected HEK293T cells. Yoda1 slows the inactivation phase of murine Piezo1 transient currents and...
| Schlagworte: | 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine |
| Anwendung: | Piezo1 agonist |
| CAS | 448947-81-7 |
| MW: | 355.3 D |
ab 53,00 €
KC159
Artikelnummer: Cay43640-1
A Piezo1 agonist, induces calcium influx in HEK cells overexpressing mouse Piezo1 (EC50 = 280 nM), induces inward currents in a whole-cell patch-clamp assay using HEK cells overexpressing mouse Piezo1 at 10 µM, induces smooth muscle relaxation in isolated and perfused mouse portal veins (EC50s = 1.14 µM)....
| Schlagworte: | 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoic acid |
| Anwendung: | Piezo1 agonist |
| MW: | 397.29 D |
ab 58,00 €
Anti-PIEZO1 / FAM38A
Artikelnummer: ARG57978.100
Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining...
| Schlagworte: | Anti-Mib, Anti-PIEZO1, Anti-FAM38A, Anti-Protein FAM38A, Anti-Membrane protein induced by beta-amyloid treatment,... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
707,00 €
Anti-PIEZO2
Artikelnummer: E-AB-17942.120
The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in...
| Schlagworte: | Anti-PIEZO2, Anti-C18orf30, Anti-Protein FAM38B, Anti-Piezo-type mechanosensitive ion channel component 2, PIEZO2... |
| Anwendung: | IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
ab 89,00 €
Anti-PIEZO1, clone CL9714
Artikelnummer: ATA-AMAb91589.100
Protein function: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining...
| Schlagworte: | Anti-Mib, Anti-PIEZO1, Anti-FAM38A, Anti-Protein FAM38A, Anti-Membrane protein induced by beta-amyloid treatment,... |
| Anwendung: | WB, IHC |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human |
ab 369,00 €
Anti-PIEZO2
Artikelnummer: ATA-HPA015986.100
Protein function: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...
| Schlagworte: | Anti-PIEZO2, Anti-C18orf30, Anti-Protein FAM38B, Anti-Piezo-type mechanosensitive ion channel component 2 |
| Anwendung: | IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Anti-PIEZO2
Artikelnummer: ATA-HPA031975.100
Protein function: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added...
| Schlagworte: | Anti-PIEZO2, Anti-C18orf30, Anti-Protein FAM38B, Anti-Piezo-type mechanosensitive ion channel component 2 |
| Anwendung: | ICC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 330,00 €
Dooku1
Artikelnummer: Cay39161-10
Dooku1 is an antagonist of yoda1-activated Piezo1 ion channels (IC50 = 1.3 µM in HEK293 cells expressing the human receptor). It is selective for Piezo1 activated by yoda1 (Cay-21904) over constituitively active Piezo1, transient receptor potential vanilloid 4 (TRPV4), and transient receptor potential canonical 4...
| Schlagworte: | 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole |
| Anwendung: | Yoda1-activated Piezo1 antagonist |
| CAS | 2253744-54-4 |
| MW: | 326.2 D |
ab 145,00 €
Piezo-type mechanosensitive ion channel component 2...
Artikelnummer: CSB-EP887983HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2427-2661aa. Protein Length: Partial. Tag Info: C-terminal 6xHis-tagged. Target Protein Sequence: KSVAGVINQP LDVSVTITLG GYQPIFTMSA QQSQLKVMDQ QSFNKFIQAF SRDTGAMQFL ENYEKEDITV AELEGNSNSL WTISPPSKQK MIHELLDPNS SFSVVFSWSI QRNLSLGAKS EIATDKLSFP...
| Schlagworte: | PIEZO2, C18orf30, Protein FAM38B, Piezo-type mechanosensitive ion channel component 2, Recombinant Human Piezo-type... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 33.3 kD |
ab 292,00 €
Piezo-type mechanosensitive ion channel component 1...
Artikelnummer: CSB-EP852881HU.1
Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 2198-2431aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: RSVVGVVNQP IDVTVTLKLG GYEPLFTMSA QQPSIIPFTA QAYEELSRQF DPQPLAMQFI SQYSPEDIVT AQIEGSSGAL WRISPPSRAQ MKRELYNGTA DITLRFTWNF...
| Schlagworte: | Mib, FAM38A, PIEZO1, Protein FAM38A, Membrane protein induced by beta-amyloid treatment, Piezo-type mechanosensitive ion... |
| Anwendung: | Activity not tested |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 33.6 kD |
ab 292,00 €