DL-AP3

Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 µM and an IC50 value of 1mM for rat mGluR1alpha when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 µM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson's disease, and the increased activity of mGluR implicated in fragile X syndrome.Formal Name: 3-phosphono-alanine. CAS Number: 5652-28-8. Synonyms: DL-2-Amino-3-Phosphonopropionic Acid, NSC 30078. Molecular Formula: C3H8NO5P. Formula Weight: 169.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 2 mg/ml. SMILES: NC(CP(O)(O)=O)C(O)=O. InChi Code: InChI=1S/C3H8NO5P/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9). InChi Key: LBTABPSJONFLPO-UHFFFAOYSA-N.