Zu "K04604" wurden 55 Artikel gefunden!
Für die Filterung wurden keine Ergebnisse gefunden!
Anti-Glutamate Metabotropic Receptor 5 / GRM5
Artikelnummer: NSJ-RQ5580
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Metabotropic glutamate receptor 5 is a G protein-coupled receptor that in humans is encoded by the GRM5 gene. It is mapped to 11q14.2-q14.3. This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic...
| Schlagworte: | Anti-GRM5, Anti-mGluR5, Anti-GPRC1E, Anti-Metabotropic glutamate receptor 5, Glutamate Metabotropic Receptor 5 Antibody /... |
| Anwendung: | WB, FC, Direct ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
755,00 €
Ro 01-6128
Artikelnummer: Cay11991-5
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced...
| Schlagworte: | N-(2,2-diphenylacetyl)-carbamic acid, ethyl ester |
| Anwendung: | mGluR1 modulator |
| CAS | 302841-86-7 |
| MW: | 283.3 D |
ab 32,00 €
MPEP (hydrochloride)
Artikelnummer: Cay14536-50
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the...
| Schlagworte: | 2-methyl-6-(2-phenylethynyl)-pyridine, monohydrochloride |
| Anwendung: | mGlu5a receptor antagonist |
| CAS | 219911-35-0 |
| MW: | 229.7 D |
ab 66,00 €
MTEP (hydrochloride)
Artikelnummer: Cay14961-10
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the...
| Schlagworte: | 3-[2-(2-methyl-4-thiazolyl)ethynyl]-pyridine, monohydrochloride |
| Anwendung: | mGlu5a receptor antagonist |
| CAS | 1186195-60-7 |
| MW: | 236.7 D |
ab 44,00 €
NPS 2390
Artikelnummer: Cay11989-10
Metabotropic glutamate receptors (mGluRs), mediate excitatory synaptic transmission in the central nervous system. Potent and selective antagonists of the type I mGluRs (mGluR1 and mGluR5) are of interest as novel therapeutics for the treatment of various CNS disorders, such as pain, epilepsy, and stroke. NPS 2390...
| Schlagworte: | N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide |
| Anwendung: | mGluR1/mGluR5 antagonist |
| CAS | 226878-01-9 |
| MW: | 307.4 D |
ab 119,00 €
(R,S)-CHPG
Artikelnummer: Cay21408-5
(R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 µM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells. In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9...
| Schlagworte: | Chlorohydroxyphenylglycine, CHPG, alpha-amino-2-chloro-5-hydroxy-benzeneacetic acid |
| Anwendung: | mGluR5 agonist |
| CAS | 170846-74-9 |
| MW: | 201.6 D |
ab 66,00 €
CDPPB
Artikelnummer: Cay34132-5
CDPPB is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGluR5). It potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s = 10 and 20 nM for the human and rat receptor, respectively). CDPPB (30 mg/kg, s.c.) inhibits amphetamine-induced...
| Schlagworte: | 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)-benzamide |
| Anwendung: | MGluR5 positive allosteric modulator |
| CAS | 781652-57-1 |
| MW: | 364.4 D |
ab 44,00 €
Anti-mGluR1 + mGluR5, clone S75-33
Artikelnummer: ARG22244.50
Protein function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and...
| Schlagworte: | Anti-Grm5, Anti-mGluR5, Anti-Gprc1e, Anti-Metabotropic glutamate receptor 5 |
| Anwendung: | WB, IHC, ICC, IF |
| Wirt: | Mouse |
| Spezies-Reaktivität: | human, mouse, rat |
520,00 €
DL-AP3
Artikelnummer: Cay13852-100
Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 µM and an IC50 value of 1mM for rat mGluR1alpha when...
| Schlagworte: | DL-2-Amino-3-Phosphonopropionic Acid, NSC 30078, 3-phosphono-alanine |
| Anwendung: | mGluR1 antagonist |
| CAS | 5652-28-8 |
| MW: | 169.1 D |
ab 50,00 €
(S)-MCPG
Artikelnummer: Cay21450-5
(S)-MCPG is an antagonist of metabotropic glutamate receptors (mGluRs) and the active component of (±)-MCPG, which is selective for Group I and Group II mGluRs. (S)-MCPG inhibits motoneuron depolarization induced by 1-amino-1,3-dicarboxycyclopentane (ACPD) in neonatal rat spinal cord in vitro and ACPD-induced...
| Schlagworte: | (+)-MCPG, (+)-alpha-methyl-4-Carboxyphenylglycine, (S)-alpha-methyl-4-Carboxyphenylglycine,... |
| Anwendung: | Non-selective group I/group II metabotropic glutamate receptor antagonist |
| CAS | 150145-89-4 |
| MW: | 209.2 D |
ab 89,00 €
Mouse Grm5 / Metabotropic glutamate receptor 5 ELISA Kit
Artikelnummer: G-MOFI00443.96
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
694,00 €
Anti-mGluR5/1a
Artikelnummer: 612-401-D77
Anti-mGluR5/1a antibody is directed against GluR5/1a. GluR5/1a antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to generate the antibody. The antibody is a total IgG fraction. Expect...
| Schlagworte: | Anti-Grm5, Anti-Gprc1e, Anti-mGluR5, Anti-Metabotropic glutamate receptor 5 |
| Anwendung: | IHC, WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | rat, human, mouse |
684,00 €