Dimethylamino-Micheliolide

Dimethylamino-micheliolide (DMAMCL) is a prodrug form of the sesquiterpene lactone micheliolide (Cay-25402). It inhibits migration and invasion of, and vascular formation by, U-118 MG glioma cells when used at a concentration of 10 µM. DMAMCL enhances cell death induced by the DNA-cross-linking agent cisplatin (Cay-13119) in U-118 MG cells. In vivo, DMAMCL (200 mg/kg) reduces tumor volume and slows the tumor growth rate in a U-118 MG mouse xenograft model when administered in combination with cisplatin. It also prevents proteinuria and renal failure in a db/db mouse model of diabetic nephropathy.Formal Name: (3R,3aS,9R,9aS,9bS)-3-[(dimethylamino)methyl]-3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-azuleno[4,5-b]furan-2(3H)-one. CAS Number: 1403357-81-2. Synonyms: ACT001, DMAMCL, Dimethylaminomicheliolide. Molecular Formula: C17H27NO3. Formula Weight: 293.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: CC1=C2[C@@]([C@@](O)(C)CC2)([H])[C@]3([H])[C@@]([C@H](CN(C)C)C(O3)=O)([H])CC1. InChi Code: InChI=1S/C17H27NO3/c1-10-5-6-12-13(9-18(3)4)16(19)21-15(12)14-11(10)7-8-17(14,2)20/h12-15,20H,5-9H2,1-4H3/t12-,13-,14-,15-,17+/m0/s1. InChi Key: ZPBIJIIQXPRJSS-WNZSCWOMSA-N. Origin: Synthetic.