Zu "K00873" wurden 116 Artikel gefunden!
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NEU
Dimethylamino-Micheliolide
Artikelnummer: Cay25499-1
Dimethylamino-micheliolide (DMAMCL) is a prodrug form of the sesquiterpene lactone micheliolide (Cay-25402). It inhibits migration and invasion of, and vascular formation by, U-118 MG glioma cells when used at a concentration of 10 µM. DMAMCL enhances cell death induced by the DNA-cross-linking agent cisplatin...
| Schlagworte: | ACT001, Dimethylaminomicheliolide, DMAMCL,... |
| Anwendung: | Micheliolide prodrug form |
| CAS | 1403357-81-2 |
| MW: | 293.4 D |
ab 114,00 €
Anti-Pyruvate Kinase / PKM2
Artikelnummer: NSJ-F54909-0.08ML
In 1X PBS, pH 7.4, with 0.09% sodium azide. PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to...
| Schlagworte: | Anti-p58, Anti-PKM, Anti-THBP1, Anti-CTHBP, Anti-OIP-3, Anti-Tumor M2-PK, Anti-Pyruvate kinase 2/3, Anti-Pyruvate kinase... |
| Anwendung: | FC, IHC (paraffin), WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 326,00 €
Anti-Pyruvate Kinase / PKM2, clone GCB-16
Artikelnummer: NSJ-RQ5429
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. The PKM gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to...
| Schlagworte: | Anti-PKM, Anti-p58, Anti-THBP1, Anti-OIP-3, Anti-CTHBP, Anti-Tumor M2-PK, Anti-Pyruvate kinase PKM, Anti-Pyruvate kinase... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
755,00 €
Human PKM2 (Pyruvate Kinase, Muscle) ELISA Kit
Artikelnummer: ELK-ELK1514.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PKM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PKM2. Next,...
| Schlagworte: | PKM, p58, OIP-3, THBP1, CTHBP, Tumor M2-PK, Pyruvate kinase PKM, Pyruvate kinase 2/3, Opa-interacting protein 3,... |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | human |
ab 365,00 €
Rat PKM2 (Pyruvate Kinase, Muscle) ELISA Kit
Artikelnummer: ELK-ELK1515.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat PKM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PKM2. Next,...
| Schlagworte: | Pkm, Pkm2, Pyruvate kinase PKM, Tyrosine-protein kinase PKM2, Threonine-protein kinase PKM2, Pyruvate kinase muscle isozyme |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | rat |
ab 365,00 €
Mouse PKM2 (Pyruvate Kinase, Muscle) ELISA Kit
Artikelnummer: ELK-ELK1516.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse PKM2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PKM2. Next,...
| Schlagworte: | Pk3, Pkm, Pyruvate kinase PKM, Tyrosine-protein kinase PKM2, Threonine-protein kinase PKM2, Pyruvate kinase muscle isozyme |
| Anwendung: | ELISA |
| Spezies-Reaktivität: | mouse |
ab 365,00 €
ML-202
Artikelnummer: Cay37326-1
ML-202 is an activator of pyruvate kinase M2 (PKM2). It induces PMK2 activation in a cell-free assay with a 50% activation concentration (AC50) value of 73 nM.Formal Name: 4,6-dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one. CAS Number: 1221186-52-2....
| Schlagworte: | 4,6-dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one |
| Anwendung: | PKM2 activator |
| CAS | 1221186-52-2 |
| MW: | 387.5 D |
ab 48,00 €
ML-265
Artikelnummer: Cay13942-10
Pyruvate kinase catalyzes the final step in glycolysis, the formation of pyruvate and ATP from phosphoenolpyruvate and ADP. The expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in the metabolic reprogramming of tumor cells, which require high amounts of glucose for proliferation. PKM2...
| Schlagworte: | CID-44246499, NCGC00186528, TEPP-46,... |
| Anwendung: | PKM2 activator |
| CAS | 1221186-53-3 |
| MW: | 372.5 D |
ab 64,00 €
DASA-58
Artikelnummer: Cay13941-10
DASA-58 is a selective activator of pyruvate kinase M2 (PKM2, AC50 = 38 nM in vitro, EC50 = 19.6 µM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1alpha by...
| Schlagworte: | ML-203, NCGC00185916, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-benzenamine |
| Anwendung: | PKM2 activator |
| CAS | 1203494-49-8 |
| MW: | 453.5 D |
ab 60,00 €
Anti-PKM2
Artikelnummer: A303-659A
Protein function: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric...
| Schlagworte: | Anti-p58, Anti-PKM, Anti-OIP3, Anti-OIP-3, Anti-CTHBP, Anti-THBP1, EC=2.7.1.40, Anti-Tumor M2-PK, Anti-Pyruvate kinase... |
| Anwendung: | WB, IP, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
PKM2 (PKM2/Variant 1), His-tag
Artikelnummer: BPS-50295
Active human Pyruvate kinase M2 (PKM2) (GenBank Accession No. NM_002654) full length with N-terminal His tag, MW = 58.9 kDa, expressed in an E. coli expression system.
| Schlagworte: | p58, PKM, THBP1, CTHBP, OIP-3, Tumor M2-PK, Pyruvate kinase PKM, Pyruvate kinase 2/3, Opa-interacting protein 3,... |
| Anwendung: | Enzyme kinetics, inhibitor screening |
| MW: | 58.9 kD |
745,00 €
Anti-PKM2
Artikelnummer: E-AB-13771.20
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor...
| Schlagworte: | Anti-p58, Anti-PKM, Anti-OIP3, Anti-CTHBP, Anti-OIP-3, Anti-THBP1, EC=2.7.1.40, Anti-Tumor M2-PK, Anti-Pyruvate kinase... |
| Anwendung: | WB, IHC, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse, rat |
ab 71,00 €